Cargando…
Production of bispecific antibodies in “knobs-into-holes” using a cell-free expression system
Bispecific antibodies have emerged in recent years as a promising field of research for therapies in oncology, inflammable diseases, and infectious diseases. Their capability of dual target recognition allows for novel therapeutic hypothesis to be tested, where traditional mono-specific antibodies w...
Autores principales: | Xu, Yiren, Lee, John, Tran, Cuong, Heibeck, Tyler H, Wang, Willie D, Yang, Junhao, Stafford, Ryan L, Steiner, Alexander R, Sato, Aaron K, Hallam, Trevor J, Yin, Gang |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623329/ https://www.ncbi.nlm.nih.gov/pubmed/25427258 http://dx.doi.org/10.4161/19420862.2015.989013 |
Ejemplares similares
-
Vector design for enhancing expression level and assembly of knob-into-hole based FabscFv-Fc bispecific antibodies in CHO cells
por: Ong, Han Kee, et al.
Publicado: (2022) -
Immunization with cell‐free‐generated vaccine protects from Porphyromonas gingivalis‐induced alveolar bone loss
por: Huang, Nasi, et al.
Publicado: (2019) -
Effect of allotypic variation of human IgG1 on the thermal stability of disulfide-linked knobs-into-holes mutants of the Fc for stable bispecific antibody design
por: Akiba, Hiroki, et al.
Publicado: (2019) -
RF1 attenuation enables efficient non-natural amino acid incorporation for production of homogeneous antibody drug conjugates
por: Yin, Gang, et al.
Publicado: (2017) -
Detailed Analytical Characterization of a Bispecific
IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various
Stress Conditions Revealed Pronounced Stability
por: Grunert, Ingrid, et al.
Publicado: (2022)