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Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma
PURPOSE: Osteoporosis is currently receiving particular attention as a sequela in survivors of childhood osteosarcoma. The aim of this study was to evaluate bone mineral density (BMD) changes during methotrexate-based chemotherapy in children and adolescents with osteosarcoma. METHODS: Nine patients...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society of Pediatric Endocrinology
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623343/ https://www.ncbi.nlm.nih.gov/pubmed/26512351 http://dx.doi.org/10.6065/apem.2015.20.3.150 |
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author | Ahn, Ju Hyun Cho, Wan Hyeong Lee, Jun Ah Kim, Dong Ho Seo, Ju-Hee Lim, Jung Sub |
author_facet | Ahn, Ju Hyun Cho, Wan Hyeong Lee, Jun Ah Kim, Dong Ho Seo, Ju-Hee Lim, Jung Sub |
author_sort | Ahn, Ju Hyun |
collection | PubMed |
description | PURPOSE: Osteoporosis is currently receiving particular attention as a sequela in survivors of childhood osteosarcoma. The aim of this study was to evaluate bone mineral density (BMD) changes during methotrexate-based chemotherapy in children and adolescents with osteosarcoma. METHODS: Nine patients with osteosarcoma were included in this retrospective study and compared with eight healthy controls. BMD of the lumbar spine and unaffected femur neck of patients was serially measured by dual-energy x-ray absorptiometry (DXA) before and just after chemotherapy and compared with controls. RESULTS: Four patients (44%) showed decreased lumbar spine BMD and seven patients (78%) showed decreased femur neck BMD, while all controls showed increased lumbar and femur BMD (P=0.024 and P=0.023). The femur neck BMD z-scores decreased from -0.49±1.14 to -1.63±1.50 (P=0.032). At the end of therapy, five patients (56%) showed femur neck BMD z-scores below -2.0. CONCLUSION: The bone metabolism is disturbed during therapy in children with osteosarcoma, resulting in a reduced BMD with respect to healthy controls. Since a reduced BMD predisposes to osteoporosis, specific attention and therapeutic interventions should be considered. |
format | Online Article Text |
id | pubmed-4623343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Society of Pediatric Endocrinology |
record_format | MEDLINE/PubMed |
spelling | pubmed-46233432015-10-28 Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma Ahn, Ju Hyun Cho, Wan Hyeong Lee, Jun Ah Kim, Dong Ho Seo, Ju-Hee Lim, Jung Sub Ann Pediatr Endocrinol Metab Original Article PURPOSE: Osteoporosis is currently receiving particular attention as a sequela in survivors of childhood osteosarcoma. The aim of this study was to evaluate bone mineral density (BMD) changes during methotrexate-based chemotherapy in children and adolescents with osteosarcoma. METHODS: Nine patients with osteosarcoma were included in this retrospective study and compared with eight healthy controls. BMD of the lumbar spine and unaffected femur neck of patients was serially measured by dual-energy x-ray absorptiometry (DXA) before and just after chemotherapy and compared with controls. RESULTS: Four patients (44%) showed decreased lumbar spine BMD and seven patients (78%) showed decreased femur neck BMD, while all controls showed increased lumbar and femur BMD (P=0.024 and P=0.023). The femur neck BMD z-scores decreased from -0.49±1.14 to -1.63±1.50 (P=0.032). At the end of therapy, five patients (56%) showed femur neck BMD z-scores below -2.0. CONCLUSION: The bone metabolism is disturbed during therapy in children with osteosarcoma, resulting in a reduced BMD with respect to healthy controls. Since a reduced BMD predisposes to osteoporosis, specific attention and therapeutic interventions should be considered. The Korean Society of Pediatric Endocrinology 2015-09 2015-09-30 /pmc/articles/PMC4623343/ /pubmed/26512351 http://dx.doi.org/10.6065/apem.2015.20.3.150 Text en © 2015 Annals of Pediatric Endocrinology & Metabolism http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ahn, Ju Hyun Cho, Wan Hyeong Lee, Jun Ah Kim, Dong Ho Seo, Ju-Hee Lim, Jung Sub Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma |
title | Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma |
title_full | Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma |
title_fullStr | Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma |
title_full_unstemmed | Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma |
title_short | Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma |
title_sort | bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623343/ https://www.ncbi.nlm.nih.gov/pubmed/26512351 http://dx.doi.org/10.6065/apem.2015.20.3.150 |
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