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Real-life assessment of the validity of patient global impression of change in fibromyalgia

OBJECTIVES: Patient Global Rating of Change (GRC) scales are commonly used in routine clinical care given their ease of use, availability and short completion time. This analysis aimed at assessing the validity of Patient Global Impression of Change (PGIC), a GRC scale commonly used in fibromyalgia,...

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Autores principales: Rampakakis, Emmanouil, Ste-Marie, Peter A, Sampalis, John S, Karellis, Angeliki, Shir, Yoram, Fitzcharles, Mary-Ann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623367/
https://www.ncbi.nlm.nih.gov/pubmed/26535150
http://dx.doi.org/10.1136/rmdopen-2015-000146
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author Rampakakis, Emmanouil
Ste-Marie, Peter A
Sampalis, John S
Karellis, Angeliki
Shir, Yoram
Fitzcharles, Mary-Ann
author_facet Rampakakis, Emmanouil
Ste-Marie, Peter A
Sampalis, John S
Karellis, Angeliki
Shir, Yoram
Fitzcharles, Mary-Ann
author_sort Rampakakis, Emmanouil
collection PubMed
description OBJECTIVES: Patient Global Rating of Change (GRC) scales are commonly used in routine clinical care given their ease of use, availability and short completion time. This analysis aimed at assessing the validity of Patient Global Impression of Change (PGIC), a GRC scale commonly used in fibromyalgia, in a Canadian real-life setting. METHODS: 167 fibromyalgia patients with available PGIC data were recruited in 2005–2013 from a Canadian tertiary-care multidisciplinary clinic. In addition to PGIC, disease severity was assessed with: pain visual analogue scale (VAS); Patient Global Assessment (PGA); Fibromyalgia Impact Questionnaire (FIQ); Health Assessment Questionnaire (HAQ); McGill Pain Questionnaire; body map. Multivariate linear regression assessed the PGIC relationship with disease parameter improvement while adjusting for follow-up duration and baseline parameter levels. The Spearman's rank coefficient assessed parameter correlation. RESULTS: Higher PGIC scores were significantly (p<0.001) associated with greater improvement in pain, PGA, FIQ, HAQ and the body map. A statistically significant moderate positive correlation was observed between PGIC and FIQ improvement (r=0.423; p<0.001); correlation with all remaining disease severity measures was weak. Regression analysis confirmed a significant (p<0.001) positive association between improvement in all disease severity measures and PGIC. Baseline disease severity and follow-up duration were identified as significant independent predictors of PGIC rating. CONCLUSIONS: Despite that only a weak correlation was identified between PGIC and standard fibromyalgia outcomes improvement, in the absence of objective outcomes, PGIC remains a clinically relevant tool to assess perceived impact of disease management. However, our analysis suggests that outcome measures data should not be considered in isolation but, within the global clinical context.
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spelling pubmed-46233672015-11-03 Real-life assessment of the validity of patient global impression of change in fibromyalgia Rampakakis, Emmanouil Ste-Marie, Peter A Sampalis, John S Karellis, Angeliki Shir, Yoram Fitzcharles, Mary-Ann RMD Open Pain OBJECTIVES: Patient Global Rating of Change (GRC) scales are commonly used in routine clinical care given their ease of use, availability and short completion time. This analysis aimed at assessing the validity of Patient Global Impression of Change (PGIC), a GRC scale commonly used in fibromyalgia, in a Canadian real-life setting. METHODS: 167 fibromyalgia patients with available PGIC data were recruited in 2005–2013 from a Canadian tertiary-care multidisciplinary clinic. In addition to PGIC, disease severity was assessed with: pain visual analogue scale (VAS); Patient Global Assessment (PGA); Fibromyalgia Impact Questionnaire (FIQ); Health Assessment Questionnaire (HAQ); McGill Pain Questionnaire; body map. Multivariate linear regression assessed the PGIC relationship with disease parameter improvement while adjusting for follow-up duration and baseline parameter levels. The Spearman's rank coefficient assessed parameter correlation. RESULTS: Higher PGIC scores were significantly (p<0.001) associated with greater improvement in pain, PGA, FIQ, HAQ and the body map. A statistically significant moderate positive correlation was observed between PGIC and FIQ improvement (r=0.423; p<0.001); correlation with all remaining disease severity measures was weak. Regression analysis confirmed a significant (p<0.001) positive association between improvement in all disease severity measures and PGIC. Baseline disease severity and follow-up duration were identified as significant independent predictors of PGIC rating. CONCLUSIONS: Despite that only a weak correlation was identified between PGIC and standard fibromyalgia outcomes improvement, in the absence of objective outcomes, PGIC remains a clinically relevant tool to assess perceived impact of disease management. However, our analysis suggests that outcome measures data should not be considered in isolation but, within the global clinical context. BMJ Publishing Group 2015-09-14 /pmc/articles/PMC4623367/ /pubmed/26535150 http://dx.doi.org/10.1136/rmdopen-2015-000146 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Pain
Rampakakis, Emmanouil
Ste-Marie, Peter A
Sampalis, John S
Karellis, Angeliki
Shir, Yoram
Fitzcharles, Mary-Ann
Real-life assessment of the validity of patient global impression of change in fibromyalgia
title Real-life assessment of the validity of patient global impression of change in fibromyalgia
title_full Real-life assessment of the validity of patient global impression of change in fibromyalgia
title_fullStr Real-life assessment of the validity of patient global impression of change in fibromyalgia
title_full_unstemmed Real-life assessment of the validity of patient global impression of change in fibromyalgia
title_short Real-life assessment of the validity of patient global impression of change in fibromyalgia
title_sort real-life assessment of the validity of patient global impression of change in fibromyalgia
topic Pain
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623367/
https://www.ncbi.nlm.nih.gov/pubmed/26535150
http://dx.doi.org/10.1136/rmdopen-2015-000146
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