A bi-functional antibody-receptor domain fusion protein simultaneously targeting IGF-IR and VEGF for degradation

Bi-specific antibodies (BsAbs), which can simultaneously block 2 tumor targets, have emerged as promising therapeutic alternatives to combinations of individual monoclonal antibodies. Here, we describe the engineering and development of a novel, human bi-functional antibody-receptor domain fusion mo...

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Detalles Bibliográficos
Autores principales: Shen, Yang, Zeng, Lin, Novosyadlyy, Ruslan, Forest, Amelie, Zhu, Aiping, Korytko, Andrew, Zhang, Haifan, Eastman, Scott W, Topper, Michael, Hindi, Sagit, Covino, Nicole, Persaud, Kris, Kang, Yun, Burtrum, Douglas, Surguladze, David, Prewett, Marie, Chintharlapalli, Sudhakar, Wroblewski, Victor J, Shen, Juqun, Balderes, Paul, Zhu, Zhenping, Snavely, Marshall, Ludwig, Dale L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623440/
https://www.ncbi.nlm.nih.gov/pubmed/26073904
http://dx.doi.org/10.1080/19420862.2015.1055442

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