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Standardization and quality control parameters for Muktā Bhasma (calcined pearl)
BACKGROUND: Muktā Bhasma (MB) is a traditional Ayurvedic preparation for cough, breathlessness, and eye disorders and is a powerful cardiac tonic, mood elevator, and known to promote strength, intellect, and semen production. OBJECTIVES: The present research work was conducted to generate fingerprin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623633/ https://www.ncbi.nlm.nih.gov/pubmed/26600667 http://dx.doi.org/10.4103/0257-7941.164542 |
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author | Joshi, Namrata Sharma, Khemchand Peter, Hema Dash, Manoj Kumar |
author_facet | Joshi, Namrata Sharma, Khemchand Peter, Hema Dash, Manoj Kumar |
author_sort | Joshi, Namrata |
collection | PubMed |
description | BACKGROUND: Muktā Bhasma (MB) is a traditional Ayurvedic preparation for cough, breathlessness, and eye disorders and is a powerful cardiac tonic, mood elevator, and known to promote strength, intellect, and semen production. OBJECTIVES: The present research work was conducted to generate fingerprint for raw and processed MB for quality assessment and standardization using classical and other techniques. SETTING AND DESIGN: Three samples of MB were prepared by purification (śodhana) of Muktā (pearl) followed by repeated calcinations (Māraṇa). Resultant product was subjected to organoleptic tests and Ayurvedic tests for quality control such as rekhāpūrṇatā, vāritaratva, and nirdhūmatva. MATERIALS AND METHODS: For quality control, physicochemical parameters such as loss on drying, total ash value, acid insoluble ash, specific gravity, pH value, and other tests using techniques such as elemental analysis with energy dispersive X-ray analysis (EDAX), Structural study with powder X-ray diffraction, particle size with scanning electron microscopy (SEM) were carried out on raw Muktā, Śodhita Muktā, and triplicate batches of MB. RESULTS: The study showed that the raw material Muktā was calcium carbonate in aragonite form, which on repeated calcinations was converted into a more stable calcite form. SEM studies revealed that in raw and purified materials the particles were found scattered and unevenly arranged in the range of 718.7–214.7 nm while in final product, uniformly arranged, stable, rod-shaped, and rounded particles with more agglomerates were observed in the range of 279.2–79.93 nm. EDAX analysis revealed calcium as a major ingredient in MB (average 46.32%) which increased gradually in the stages of processing (raw 34.11%, Śodhita 37.5%). CONCLUSION: Quality control parameters have been quantified for fingerprinting of MB prepared using a particular method. |
format | Online Article Text |
id | pubmed-4623633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-46236332015-11-23 Standardization and quality control parameters for Muktā Bhasma (calcined pearl) Joshi, Namrata Sharma, Khemchand Peter, Hema Dash, Manoj Kumar Anc Sci Life Original Article BACKGROUND: Muktā Bhasma (MB) is a traditional Ayurvedic preparation for cough, breathlessness, and eye disorders and is a powerful cardiac tonic, mood elevator, and known to promote strength, intellect, and semen production. OBJECTIVES: The present research work was conducted to generate fingerprint for raw and processed MB for quality assessment and standardization using classical and other techniques. SETTING AND DESIGN: Three samples of MB were prepared by purification (śodhana) of Muktā (pearl) followed by repeated calcinations (Māraṇa). Resultant product was subjected to organoleptic tests and Ayurvedic tests for quality control such as rekhāpūrṇatā, vāritaratva, and nirdhūmatva. MATERIALS AND METHODS: For quality control, physicochemical parameters such as loss on drying, total ash value, acid insoluble ash, specific gravity, pH value, and other tests using techniques such as elemental analysis with energy dispersive X-ray analysis (EDAX), Structural study with powder X-ray diffraction, particle size with scanning electron microscopy (SEM) were carried out on raw Muktā, Śodhita Muktā, and triplicate batches of MB. RESULTS: The study showed that the raw material Muktā was calcium carbonate in aragonite form, which on repeated calcinations was converted into a more stable calcite form. SEM studies revealed that in raw and purified materials the particles were found scattered and unevenly arranged in the range of 718.7–214.7 nm while in final product, uniformly arranged, stable, rod-shaped, and rounded particles with more agglomerates were observed in the range of 279.2–79.93 nm. EDAX analysis revealed calcium as a major ingredient in MB (average 46.32%) which increased gradually in the stages of processing (raw 34.11%, Śodhita 37.5%). CONCLUSION: Quality control parameters have been quantified for fingerprinting of MB prepared using a particular method. Medknow Publications & Media Pvt Ltd 2015 /pmc/articles/PMC4623633/ /pubmed/26600667 http://dx.doi.org/10.4103/0257-7941.164542 Text en Copyright: © Ancient Science of Life http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Joshi, Namrata Sharma, Khemchand Peter, Hema Dash, Manoj Kumar Standardization and quality control parameters for Muktā Bhasma (calcined pearl) |
title | Standardization and quality control parameters for Muktā Bhasma (calcined pearl) |
title_full | Standardization and quality control parameters for Muktā Bhasma (calcined pearl) |
title_fullStr | Standardization and quality control parameters for Muktā Bhasma (calcined pearl) |
title_full_unstemmed | Standardization and quality control parameters for Muktā Bhasma (calcined pearl) |
title_short | Standardization and quality control parameters for Muktā Bhasma (calcined pearl) |
title_sort | standardization and quality control parameters for muktā bhasma (calcined pearl) |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623633/ https://www.ncbi.nlm.nih.gov/pubmed/26600667 http://dx.doi.org/10.4103/0257-7941.164542 |
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