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Seeing and believing: recent advances in imaging cell-cell interactions
Advances in cell and developmental biology have often been closely linked to advances in our ability to visualize structure and function at many length and time scales. In this review, we discuss how new imaging technologies and new reagents have provided novel insights into the biology of cadherin-...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623898/ https://www.ncbi.nlm.nih.gov/pubmed/26543555 http://dx.doi.org/10.12688/f1000research.6435.1 |
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author | Yap, Alpha S. Michael, Magdalene Parton, Robert G. |
author_facet | Yap, Alpha S. Michael, Magdalene Parton, Robert G. |
author_sort | Yap, Alpha S. |
collection | PubMed |
description | Advances in cell and developmental biology have often been closely linked to advances in our ability to visualize structure and function at many length and time scales. In this review, we discuss how new imaging technologies and new reagents have provided novel insights into the biology of cadherin-based cell-cell junctions. We focus on three developments: the application of super-resolution optical technologies to characterize the nanoscale organization of cadherins at cell-cell contacts, new approaches to interrogate the mechanical forces that act upon junctions, and advances in electron microscopy which have the potential to transform our understanding of cell-cell junctions. |
format | Online Article Text |
id | pubmed-4623898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | F1000Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-46238982015-11-04 Seeing and believing: recent advances in imaging cell-cell interactions Yap, Alpha S. Michael, Magdalene Parton, Robert G. F1000Res Review Advances in cell and developmental biology have often been closely linked to advances in our ability to visualize structure and function at many length and time scales. In this review, we discuss how new imaging technologies and new reagents have provided novel insights into the biology of cadherin-based cell-cell junctions. We focus on three developments: the application of super-resolution optical technologies to characterize the nanoscale organization of cadherins at cell-cell contacts, new approaches to interrogate the mechanical forces that act upon junctions, and advances in electron microscopy which have the potential to transform our understanding of cell-cell junctions. F1000Research 2015-07-17 /pmc/articles/PMC4623898/ /pubmed/26543555 http://dx.doi.org/10.12688/f1000research.6435.1 Text en Copyright: © 2015 Yap AS et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Yap, Alpha S. Michael, Magdalene Parton, Robert G. Seeing and believing: recent advances in imaging cell-cell interactions |
title | Seeing and believing: recent advances in imaging cell-cell interactions |
title_full | Seeing and believing: recent advances in imaging cell-cell interactions |
title_fullStr | Seeing and believing: recent advances in imaging cell-cell interactions |
title_full_unstemmed | Seeing and believing: recent advances in imaging cell-cell interactions |
title_short | Seeing and believing: recent advances in imaging cell-cell interactions |
title_sort | seeing and believing: recent advances in imaging cell-cell interactions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623898/ https://www.ncbi.nlm.nih.gov/pubmed/26543555 http://dx.doi.org/10.12688/f1000research.6435.1 |
work_keys_str_mv | AT yapalphas seeingandbelievingrecentadvancesinimagingcellcellinteractions AT michaelmagdalene seeingandbelievingrecentadvancesinimagingcellcellinteractions AT partonrobertg seeingandbelievingrecentadvancesinimagingcellcellinteractions |