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H(2)O(2)-Activated Mitochondrial Phospholipase iPLA(2)γ Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-Protein–Coupled Receptor GPR40, and Regulates Insulin Secretion in Pancreatic β-Cells

Aims: Pancreatic β-cell chronic lipotoxicity evolves from acute free fatty acid (FA)–mediated oxidative stress, unprotected by antioxidant mechanisms. Since mitochondrial uncoupling protein-2 (UCP2) plays antioxidant and insulin-regulating roles in pancreatic β-cells, we tested our hypothesis, that...

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Detalles Bibliográficos
Autores principales:	Ježek, Jan, Dlasková, Andrea, Zelenka, Jaroslav, Jabůrek, Martin, Ježek, Petr
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2015
Materias:	Original Research Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4623989/ https://www.ncbi.nlm.nih.gov/pubmed/25925080 http://dx.doi.org/10.1089/ars.2014.6195

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