Cargando…

Cortical thickness in adolescent marijuana and alcohol users: A three-year prospective study from adolescence to young adulthood

Studies suggest marijuana impacts gray and white matter neural tissue development, however few prospective studies have determined the relationship between cortical thickness and cannabis use spanning adolescence to young adulthood. This study aimed to understand how heavy marijuana use influences c...

Descripción completa

Detalles Bibliográficos
Autores principales: Jacobus, Joanna, Squeglia, Lindsay M., Meruelo, Alejandro D., Castro, Norma, Brumback, Ty, Giedd, Jay N., Tapert, Susan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624050/
https://www.ncbi.nlm.nih.gov/pubmed/25953106
http://dx.doi.org/10.1016/j.dcn.2015.04.006
_version_ 1782397770168008704
author Jacobus, Joanna
Squeglia, Lindsay M.
Meruelo, Alejandro D.
Castro, Norma
Brumback, Ty
Giedd, Jay N.
Tapert, Susan F.
author_facet Jacobus, Joanna
Squeglia, Lindsay M.
Meruelo, Alejandro D.
Castro, Norma
Brumback, Ty
Giedd, Jay N.
Tapert, Susan F.
author_sort Jacobus, Joanna
collection PubMed
description Studies suggest marijuana impacts gray and white matter neural tissue development, however few prospective studies have determined the relationship between cortical thickness and cannabis use spanning adolescence to young adulthood. This study aimed to understand how heavy marijuana use influences cortical thickness trajectories across adolescence. Subjects were adolescents with heavy marijuana use and concomitant alcohol use (MJ + ALC, n = 30) and controls (CON, n = 38) with limited substance use histories. Participants underwent magnetic resonance imaging and comprehensive substance use assessment at three independent time points. Repeated measures analysis of covariance was used to look at main effects of group, time, and Group × Time interactions on cortical thickness. MJ + ALC showed thicker cortical estimates across the brain (23 regions), particularly in frontal and parietal lobes (ps < .05). More cumulative marijuana use was associated with increased thickness estimates by 3-year follow-up (ps < .05). Heavy marijuana use during adolescence and into young adulthood may be associated with altered neural tissue development and interference with neuromaturation that can have neurobehavioral consequences. Continued follow-up of adolescent marijuana users will help understand ongoing neural changes that are associated with development of problematic use into adulthood, as well as potential for neural recovery with cessation of use.
format Online
Article
Text
id pubmed-4624050
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-46240502016-12-01 Cortical thickness in adolescent marijuana and alcohol users: A three-year prospective study from adolescence to young adulthood Jacobus, Joanna Squeglia, Lindsay M. Meruelo, Alejandro D. Castro, Norma Brumback, Ty Giedd, Jay N. Tapert, Susan F. Dev Cogn Neurosci Original Research Studies suggest marijuana impacts gray and white matter neural tissue development, however few prospective studies have determined the relationship between cortical thickness and cannabis use spanning adolescence to young adulthood. This study aimed to understand how heavy marijuana use influences cortical thickness trajectories across adolescence. Subjects were adolescents with heavy marijuana use and concomitant alcohol use (MJ + ALC, n = 30) and controls (CON, n = 38) with limited substance use histories. Participants underwent magnetic resonance imaging and comprehensive substance use assessment at three independent time points. Repeated measures analysis of covariance was used to look at main effects of group, time, and Group × Time interactions on cortical thickness. MJ + ALC showed thicker cortical estimates across the brain (23 regions), particularly in frontal and parietal lobes (ps < .05). More cumulative marijuana use was associated with increased thickness estimates by 3-year follow-up (ps < .05). Heavy marijuana use during adolescence and into young adulthood may be associated with altered neural tissue development and interference with neuromaturation that can have neurobehavioral consequences. Continued follow-up of adolescent marijuana users will help understand ongoing neural changes that are associated with development of problematic use into adulthood, as well as potential for neural recovery with cessation of use. Elsevier 2015-04-27 /pmc/articles/PMC4624050/ /pubmed/25953106 http://dx.doi.org/10.1016/j.dcn.2015.04.006 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research
Jacobus, Joanna
Squeglia, Lindsay M.
Meruelo, Alejandro D.
Castro, Norma
Brumback, Ty
Giedd, Jay N.
Tapert, Susan F.
Cortical thickness in adolescent marijuana and alcohol users: A three-year prospective study from adolescence to young adulthood
title Cortical thickness in adolescent marijuana and alcohol users: A three-year prospective study from adolescence to young adulthood
title_full Cortical thickness in adolescent marijuana and alcohol users: A three-year prospective study from adolescence to young adulthood
title_fullStr Cortical thickness in adolescent marijuana and alcohol users: A three-year prospective study from adolescence to young adulthood
title_full_unstemmed Cortical thickness in adolescent marijuana and alcohol users: A three-year prospective study from adolescence to young adulthood
title_short Cortical thickness in adolescent marijuana and alcohol users: A three-year prospective study from adolescence to young adulthood
title_sort cortical thickness in adolescent marijuana and alcohol users: a three-year prospective study from adolescence to young adulthood
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624050/
https://www.ncbi.nlm.nih.gov/pubmed/25953106
http://dx.doi.org/10.1016/j.dcn.2015.04.006
work_keys_str_mv AT jacobusjoanna corticalthicknessinadolescentmarijuanaandalcoholusersathreeyearprospectivestudyfromadolescencetoyoungadulthood
AT squeglialindsaym corticalthicknessinadolescentmarijuanaandalcoholusersathreeyearprospectivestudyfromadolescencetoyoungadulthood
AT merueloalejandrod corticalthicknessinadolescentmarijuanaandalcoholusersathreeyearprospectivestudyfromadolescencetoyoungadulthood
AT castronorma corticalthicknessinadolescentmarijuanaandalcoholusersathreeyearprospectivestudyfromadolescencetoyoungadulthood
AT brumbackty corticalthicknessinadolescentmarijuanaandalcoholusersathreeyearprospectivestudyfromadolescencetoyoungadulthood
AT gieddjayn corticalthicknessinadolescentmarijuanaandalcoholusersathreeyearprospectivestudyfromadolescencetoyoungadulthood
AT tapertsusanf corticalthicknessinadolescentmarijuanaandalcoholusersathreeyearprospectivestudyfromadolescencetoyoungadulthood