Lipid A as a Drug Target and Therapeutic Molecule

In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development. Several assay methods used to screen for inhibitors of lipi...

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Detalles Bibliográficos
Autor principal: Joo, Sang Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624066/
https://www.ncbi.nlm.nih.gov/pubmed/26535075
http://dx.doi.org/10.4062/biomolther.2015.117
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author Joo, Sang Hoon
author_facet Joo, Sang Hoon
author_sort Joo, Sang Hoon
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description In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development. Several assay methods used to screen for inhibitors of lipid A synthesis will be presented, and some of the promising lead compounds will be described. Second, utilization of lipid A biosynthetic pathways by various bacterial species can generate modified lipid A molecules with therapeutic value.
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spelling pubmed-46240662015-11-03 Lipid A as a Drug Target and Therapeutic Molecule Joo, Sang Hoon Biomol Ther (Seoul) Review In this review, lipid A, from its discovery to recent findings, is presented as a drug target and therapeutic molecule. First, the biosynthetic pathway for lipid A, the Raetz pathway, serves as a good drug target for antibiotic development. Several assay methods used to screen for inhibitors of lipid A synthesis will be presented, and some of the promising lead compounds will be described. Second, utilization of lipid A biosynthetic pathways by various bacterial species can generate modified lipid A molecules with therapeutic value. The Korean Society of Applied Pharmacology 2015-11 2015-11-01 /pmc/articles/PMC4624066/ /pubmed/26535075 http://dx.doi.org/10.4062/biomolther.2015.117 Text en Copyright ©2015, The Korean Society of Applied Pharmacology http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Joo, Sang Hoon
Lipid A as a Drug Target and Therapeutic Molecule
title Lipid A as a Drug Target and Therapeutic Molecule
title_full Lipid A as a Drug Target and Therapeutic Molecule
title_fullStr Lipid A as a Drug Target and Therapeutic Molecule
title_full_unstemmed Lipid A as a Drug Target and Therapeutic Molecule
title_short Lipid A as a Drug Target and Therapeutic Molecule
title_sort lipid a as a drug target and therapeutic molecule
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624066/
https://www.ncbi.nlm.nih.gov/pubmed/26535075
http://dx.doi.org/10.4062/biomolther.2015.117
work_keys_str_mv AT joosanghoon lipidaasadrugtargetandtherapeuticmolecule

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