Biochemical and Structural Characterization of HDAC8 Mutants Associated with Cornelia de Lange Syndrome Spectrum Disorders

[Image: see text] Cornelia de Lange Syndrome (CdLS) spectrum disorders are characterized by multiple organ system congenital anomalies that result from mutations in genes encoding core cohesin proteins SMC1A, SMC3, and RAD21, or proteins that regulate cohesin function such as NIPBL and HDAC8. HDAC8...

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Detalles Bibliográficos
Autores principales: Decroos, Christophe, Christianson, Nicolas H., Gullett, Laura E., Bowman, Christine M., Christianson, Karen E., Deardorff, Matthew A., Christianson, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624487/
https://www.ncbi.nlm.nih.gov/pubmed/26463496
http://dx.doi.org/10.1021/acs.biochem.5b00881

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