Commentary on “Inhibition of interleukin-1beta decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms”

Aortic aneurysm is a silent but life-threatening disease, whose pathogenesis remains poorly understood. Aneurysm models have been induced in small animals to study its pathogenesis, Johnston WF et al. successfully induced a novel model of thoracic aortic aneurysms (TAA) by periadventitial applicatio...

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Detalles Bibliográficos
Autores principales: Bi, Yonghua, Zhong, Hongshan, Han, Xinwei, Xu, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624566/
https://www.ncbi.nlm.nih.gov/pubmed/26587231
http://dx.doi.org/10.1016/j.amsu.2015.07.006
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author Bi, Yonghua
Zhong, Hongshan
Han, Xinwei
Xu, Ke
author_facet Bi, Yonghua
Zhong, Hongshan
Han, Xinwei
Xu, Ke
author_sort Bi, Yonghua
collection PubMed
description Aortic aneurysm is a silent but life-threatening disease, whose pathogenesis remains poorly understood. Aneurysm models have been induced in small animals to study its pathogenesis, Johnston WF et al. successfully induced a novel model of thoracic aortic aneurysms (TAA) by periadventitial application of elastase in mice. We comment on this model according to our experiment. We hypothesize that endogenous MMPs, especially MMP2, play a vital role in complex repair process of aneurysmal wall, which should be a key target in the investigation and treatment of aortic aneurysms.
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spelling pubmed-46245662015-11-19 Commentary on “Inhibition of interleukin-1beta decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms” Bi, Yonghua Zhong, Hongshan Han, Xinwei Xu, Ke Ann Med Surg (Lond) Commentary Aortic aneurysm is a silent but life-threatening disease, whose pathogenesis remains poorly understood. Aneurysm models have been induced in small animals to study its pathogenesis, Johnston WF et al. successfully induced a novel model of thoracic aortic aneurysms (TAA) by periadventitial application of elastase in mice. We comment on this model according to our experiment. We hypothesize that endogenous MMPs, especially MMP2, play a vital role in complex repair process of aneurysmal wall, which should be a key target in the investigation and treatment of aortic aneurysms. Elsevier 2015-07-26 /pmc/articles/PMC4624566/ /pubmed/26587231 http://dx.doi.org/10.1016/j.amsu.2015.07.006 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Commentary
Bi, Yonghua
Zhong, Hongshan
Han, Xinwei
Xu, Ke
Commentary on “Inhibition of interleukin-1beta decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms”
title Commentary on “Inhibition of interleukin-1beta decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms”
title_full Commentary on “Inhibition of interleukin-1beta decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms”
title_fullStr Commentary on “Inhibition of interleukin-1beta decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms”
title_full_unstemmed Commentary on “Inhibition of interleukin-1beta decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms”
title_short Commentary on “Inhibition of interleukin-1beta decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms”
title_sort commentary on “inhibition of interleukin-1beta decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms”
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624566/
https://www.ncbi.nlm.nih.gov/pubmed/26587231
http://dx.doi.org/10.1016/j.amsu.2015.07.006
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AT zhonghongshan commentaryoninhibitionofinterleukin1betadecreasesaneurysmformationandprogressioninanovelmodelofthoracicaorticaneurysms
AT hanxinwei commentaryoninhibitionofinterleukin1betadecreasesaneurysmformationandprogressioninanovelmodelofthoracicaorticaneurysms
AT xuke commentaryoninhibitionofinterleukin1betadecreasesaneurysmformationandprogressioninanovelmodelofthoracicaorticaneurysms

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