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Retinal Thickness and the Structure/Function Relationship in the Eyes of Older Adults with Glaucoma

Glaucoma is common and shows high prevalence in older adults. However, there are few studies on the structure/function relationship in older adults with glaucoma. This prospective, cross-sectional study (conducted between February and August 2014), enrolled 102 eyes of 102 subjects aged over 75 year...

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Autores principales: Honjo, Megumi, Omodaka, Kazuko, Ishizaki, Tatsuro, Ohkubo, Shinji, Araie, Makoto, Nakazawa, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624632/
https://www.ncbi.nlm.nih.gov/pubmed/26505757
http://dx.doi.org/10.1371/journal.pone.0141293
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author Honjo, Megumi
Omodaka, Kazuko
Ishizaki, Tatsuro
Ohkubo, Shinji
Araie, Makoto
Nakazawa, Toru
author_facet Honjo, Megumi
Omodaka, Kazuko
Ishizaki, Tatsuro
Ohkubo, Shinji
Araie, Makoto
Nakazawa, Toru
author_sort Honjo, Megumi
collection PubMed
description Glaucoma is common and shows high prevalence in older adults. However, there are few studies on the structure/function relationship in older adults with glaucoma. This prospective, cross-sectional study (conducted between February and August 2014), enrolled 102 eyes of 102 subjects aged over 75 years, including 57 eyes with primary open angle glaucoma (POAG), 15 eyes with pseudoexfoliation glaucoma (PXG), and 30 healthy eyes. Multiple regression analysis was used to determine the correlation of circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and macular parameters to mean deviation (MD) to and standard automated perimetry (SAP)-measured sensitivity, assessed with the 30–2 and 10–2 programs. In each 10–2 SAP test point, Spearman’s rank correlation coefficient was used to compare macular retinal nerve fiber layer thickness (mRNFLT), macular ganglion cell-inner plexiform layer thickness (GCIPLT), and mRNFL+GCIPL thickness (GCCT) with sensitivity after adjusting for retinal ganglion cell (RGC) displacement. In eyes with POAG and PXG, cpRNFLT was significantly correlated with 30–2 MD and 30–2 sensitivity. Multiple regression analysis revealed that the POAG had significantly lower cpRNFLT, mRNFLT, GCIPLT, and GCCT according to the severity of disease than control eyes after adjusting for sensitivity, age, sex, and axial length. The PXG eyes had significantly lower cpRNFLT, mRNFLT, and GCCT when compared with the early to moderate POAG eyes. GCCT was significantly correlated with 10–2 sensitivity, except in one juxtafoveal point, (r = 0.338–0.778) in the POAG eyes. The periphery of the central 10° area showed a good correlation between sensitivity and mRNFLT, while the central 5.8° showed a good correlation between sensitivity and GCIPLT. The correlation between structure and function was significant, and objective and quantitative method with OCT assessing glaucoma that does not require patient ability could be a possible parameter to assess diagnosis and progression in older patients with glaucoma.
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spelling pubmed-46246322015-11-06 Retinal Thickness and the Structure/Function Relationship in the Eyes of Older Adults with Glaucoma Honjo, Megumi Omodaka, Kazuko Ishizaki, Tatsuro Ohkubo, Shinji Araie, Makoto Nakazawa, Toru PLoS One Research Article Glaucoma is common and shows high prevalence in older adults. However, there are few studies on the structure/function relationship in older adults with glaucoma. This prospective, cross-sectional study (conducted between February and August 2014), enrolled 102 eyes of 102 subjects aged over 75 years, including 57 eyes with primary open angle glaucoma (POAG), 15 eyes with pseudoexfoliation glaucoma (PXG), and 30 healthy eyes. Multiple regression analysis was used to determine the correlation of circumpapillary retinal nerve fiber layer thickness (cpRNFLT) and macular parameters to mean deviation (MD) to and standard automated perimetry (SAP)-measured sensitivity, assessed with the 30–2 and 10–2 programs. In each 10–2 SAP test point, Spearman’s rank correlation coefficient was used to compare macular retinal nerve fiber layer thickness (mRNFLT), macular ganglion cell-inner plexiform layer thickness (GCIPLT), and mRNFL+GCIPL thickness (GCCT) with sensitivity after adjusting for retinal ganglion cell (RGC) displacement. In eyes with POAG and PXG, cpRNFLT was significantly correlated with 30–2 MD and 30–2 sensitivity. Multiple regression analysis revealed that the POAG had significantly lower cpRNFLT, mRNFLT, GCIPLT, and GCCT according to the severity of disease than control eyes after adjusting for sensitivity, age, sex, and axial length. The PXG eyes had significantly lower cpRNFLT, mRNFLT, and GCCT when compared with the early to moderate POAG eyes. GCCT was significantly correlated with 10–2 sensitivity, except in one juxtafoveal point, (r = 0.338–0.778) in the POAG eyes. The periphery of the central 10° area showed a good correlation between sensitivity and mRNFLT, while the central 5.8° showed a good correlation between sensitivity and GCIPLT. The correlation between structure and function was significant, and objective and quantitative method with OCT assessing glaucoma that does not require patient ability could be a possible parameter to assess diagnosis and progression in older patients with glaucoma. Public Library of Science 2015-10-27 /pmc/articles/PMC4624632/ /pubmed/26505757 http://dx.doi.org/10.1371/journal.pone.0141293 Text en © 2015 Honjo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Honjo, Megumi
Omodaka, Kazuko
Ishizaki, Tatsuro
Ohkubo, Shinji
Araie, Makoto
Nakazawa, Toru
Retinal Thickness and the Structure/Function Relationship in the Eyes of Older Adults with Glaucoma
title Retinal Thickness and the Structure/Function Relationship in the Eyes of Older Adults with Glaucoma
title_full Retinal Thickness and the Structure/Function Relationship in the Eyes of Older Adults with Glaucoma
title_fullStr Retinal Thickness and the Structure/Function Relationship in the Eyes of Older Adults with Glaucoma
title_full_unstemmed Retinal Thickness and the Structure/Function Relationship in the Eyes of Older Adults with Glaucoma
title_short Retinal Thickness and the Structure/Function Relationship in the Eyes of Older Adults with Glaucoma
title_sort retinal thickness and the structure/function relationship in the eyes of older adults with glaucoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624632/
https://www.ncbi.nlm.nih.gov/pubmed/26505757
http://dx.doi.org/10.1371/journal.pone.0141293
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