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The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells

The Ran GTPase activating protein RanGAP1 plays an essential role in nuclear transport by stimulating RanGTP hydrolysis in the cytoplasmic compartment. In mammalian cells, unmodified RanGAP1 is predominantly cytoplasmic, whereas modification by small ubiquitin-related modifier protein (SUMO) targets...

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Detalles Bibliográficos
Autores principales:	Cha, Keith, Sen, Progga, Raghunayakula, Sarita, Zhang, Xiang-Dong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624696/ https://www.ncbi.nlm.nih.gov/pubmed/26506250 http://dx.doi.org/10.1371/journal.pone.0141309

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