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A Single Amino Acid Mutation (R104P) in the E/DRY Motif of GPR40 Impairs Receptor Function
Type 2 Diabetes Mellitus with insulin resistance, pancreatic β cell dysfunction, and hepatic glucose overproduction is increasing in epidemic proportions worldwide. G protein-coupled receptor 40 (GPR40), a clinically proven anti-diabetic drug target, is mainly expressed in pancreatic β cells and ins...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624708/ https://www.ncbi.nlm.nih.gov/pubmed/26505901 http://dx.doi.org/10.1371/journal.pone.0141303 |