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Correlation of adrenomedullin with the erythropoietin receptor and microvessel density in hepatocellular carcinoma

INTRODUCTION: Uncontrolled angiogenesis plays an essential role in the occurrence, metastasis and malignant progression of hepatocellular carcinoma (HCC). This study aimed to investigate the expression of adrenomedullin (ADM) in human HCC and its correlation with the expression of erythropoietin rec...

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Autores principales: Qu, Zhen, Jiang, Yong, Xu, Ming, Lu, Ming Zhu, Zhou, Bin, Ding, Yitao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624742/
https://www.ncbi.nlm.nih.gov/pubmed/26528339
http://dx.doi.org/10.5114/aoms.2015.54852
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author Qu, Zhen
Jiang, Yong
Xu, Ming
Lu, Ming Zhu
Zhou, Bin
Ding, Yitao
author_facet Qu, Zhen
Jiang, Yong
Xu, Ming
Lu, Ming Zhu
Zhou, Bin
Ding, Yitao
author_sort Qu, Zhen
collection PubMed
description INTRODUCTION: Uncontrolled angiogenesis plays an essential role in the occurrence, metastasis and malignant progression of hepatocellular carcinoma (HCC). This study aimed to investigate the expression of adrenomedullin (ADM) in human HCC and its correlation with the expression of erythropoietin receptor (EPOR), microvessel density (MVD) and the tumor pathological characteristics. MATERIAL AND METHODS: Fresh tumor tissues were obtained from 30 HCC patients after hepatectomy. Ten cirrhotic and 10 normal liver tissues were included as controls. Expression of ADM and EPOR was determined by real-time PCR. The MVD was determined by counting the number of microvessels. RESULTS: The MVD and the mRNA levels of ADM and EPOR in cancer tissues were significantly higher than those in the non-cancer tissues (p < 0.05). Expression of ADM was significantly correlated with the MVD and EPOR (r = 0.68 and 0.74, p < 0.01). Adrenomedullin and EPOR mRNA levels in HCC tissues were correlated with capsule invasion, pathological differentiation and tumor metastasis (p < 0.05). CONCLUSIONS: Our findings suggest that ADM and EPOR may serve as new regulatory factors involved in angiogenesis of HCC and represent novel targets for the treatment of HCC.
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spelling pubmed-46247422015-11-02 Correlation of adrenomedullin with the erythropoietin receptor and microvessel density in hepatocellular carcinoma Qu, Zhen Jiang, Yong Xu, Ming Lu, Ming Zhu Zhou, Bin Ding, Yitao Arch Med Sci Clinical Research INTRODUCTION: Uncontrolled angiogenesis plays an essential role in the occurrence, metastasis and malignant progression of hepatocellular carcinoma (HCC). This study aimed to investigate the expression of adrenomedullin (ADM) in human HCC and its correlation with the expression of erythropoietin receptor (EPOR), microvessel density (MVD) and the tumor pathological characteristics. MATERIAL AND METHODS: Fresh tumor tissues were obtained from 30 HCC patients after hepatectomy. Ten cirrhotic and 10 normal liver tissues were included as controls. Expression of ADM and EPOR was determined by real-time PCR. The MVD was determined by counting the number of microvessels. RESULTS: The MVD and the mRNA levels of ADM and EPOR in cancer tissues were significantly higher than those in the non-cancer tissues (p < 0.05). Expression of ADM was significantly correlated with the MVD and EPOR (r = 0.68 and 0.74, p < 0.01). Adrenomedullin and EPOR mRNA levels in HCC tissues were correlated with capsule invasion, pathological differentiation and tumor metastasis (p < 0.05). CONCLUSIONS: Our findings suggest that ADM and EPOR may serve as new regulatory factors involved in angiogenesis of HCC and represent novel targets for the treatment of HCC. Termedia Publishing House 2015-10-12 2015-10-12 /pmc/articles/PMC4624742/ /pubmed/26528339 http://dx.doi.org/10.5114/aoms.2015.54852 Text en Copyright © 2015 Termedia & Banach http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Research
Qu, Zhen
Jiang, Yong
Xu, Ming
Lu, Ming Zhu
Zhou, Bin
Ding, Yitao
Correlation of adrenomedullin with the erythropoietin receptor and microvessel density in hepatocellular carcinoma
title Correlation of adrenomedullin with the erythropoietin receptor and microvessel density in hepatocellular carcinoma
title_full Correlation of adrenomedullin with the erythropoietin receptor and microvessel density in hepatocellular carcinoma
title_fullStr Correlation of adrenomedullin with the erythropoietin receptor and microvessel density in hepatocellular carcinoma
title_full_unstemmed Correlation of adrenomedullin with the erythropoietin receptor and microvessel density in hepatocellular carcinoma
title_short Correlation of adrenomedullin with the erythropoietin receptor and microvessel density in hepatocellular carcinoma
title_sort correlation of adrenomedullin with the erythropoietin receptor and microvessel density in hepatocellular carcinoma
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624742/
https://www.ncbi.nlm.nih.gov/pubmed/26528339
http://dx.doi.org/10.5114/aoms.2015.54852
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