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Maternal Chlamydia trachomatis Infections and Preterm Births in a University Hospital in Vitoria, Brazil
BACKGROUND: Preterm birth (PTB) is a major determinant of neonatal morbimortality with adverse consequences for health. The causes are multifactorial, with intrauterine infection probably explaining most of these outcomes. It is believed that infection with Chlamydia trachomatis (CT) is also involve...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624773/ https://www.ncbi.nlm.nih.gov/pubmed/26505892 http://dx.doi.org/10.1371/journal.pone.0141367 |
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author | Schmidt, Renylena Muniz, Renan Rosetti Cola, Elizandra Stauffert, Dulce Silveira, Mariangela Freitas Miranda, Angelica E. |
author_facet | Schmidt, Renylena Muniz, Renan Rosetti Cola, Elizandra Stauffert, Dulce Silveira, Mariangela Freitas Miranda, Angelica E. |
author_sort | Schmidt, Renylena |
collection | PubMed |
description | BACKGROUND: Preterm birth (PTB) is a major determinant of neonatal morbimortality with adverse consequences for health. The causes are multifactorial, with intrauterine infection probably explaining most of these outcomes. It is believed that infection with Chlamydia trachomatis (CT) is also involved in PTB and premature rupture of membranes. OBJETIVES: To evaluate the prevalence of and associated factors for CT among cases of PTB attended at a University Hospital in Vitoria, Brazil. METHODS: A cross-sectional study performed among parturient who had preterm birth from June 2012 to August 2013 in Vitoria, Brazil. Participants answered a questionnaire including demographic, behavioral, and clinical data. A sample of urine was collected and screened for CT using polymerase chain reaction. Chi-square tests were used for proportion differences and Student’s-t tests and variance analysis were used for testing differences between mean values. Odds ratio was used as a measure of association with a 95% confidence interval. RESULTS: The prevalence of PTB during the period of the study was 26% and the prevalence of CT among them was 13.9%. A total of 31.6% pregnant women were younger than 25 years old and women infected by CT were even younger than women not infected by CT (p = 0.022). Most of them (76.2%) were married or had a living partner, and CT infection was more frequent among the single ones (p = 0.018); 16.7% of women reported their first sexual intercourse under 14 years old. The causes of prematurity were maternal-fetal in 40.9%; rupture of the membranes in 29.7% and premature labor in 29.4%. In multivariate analysis, being married was a protective factor for infection [OR = 0.48 (95%CI:0.24–0.97)]. None of the other characteristics were associated with CT infection. CONCLUSIONS: This study shows a high prevalence of CT infection among parturient who have preterm birth. This high prevalence highlight the need for defining screening strategies focused on young pregnant women in Brazil. |
format | Online Article Text |
id | pubmed-4624773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46247732015-11-06 Maternal Chlamydia trachomatis Infections and Preterm Births in a University Hospital in Vitoria, Brazil Schmidt, Renylena Muniz, Renan Rosetti Cola, Elizandra Stauffert, Dulce Silveira, Mariangela Freitas Miranda, Angelica E. PLoS One Research Article BACKGROUND: Preterm birth (PTB) is a major determinant of neonatal morbimortality with adverse consequences for health. The causes are multifactorial, with intrauterine infection probably explaining most of these outcomes. It is believed that infection with Chlamydia trachomatis (CT) is also involved in PTB and premature rupture of membranes. OBJETIVES: To evaluate the prevalence of and associated factors for CT among cases of PTB attended at a University Hospital in Vitoria, Brazil. METHODS: A cross-sectional study performed among parturient who had preterm birth from June 2012 to August 2013 in Vitoria, Brazil. Participants answered a questionnaire including demographic, behavioral, and clinical data. A sample of urine was collected and screened for CT using polymerase chain reaction. Chi-square tests were used for proportion differences and Student’s-t tests and variance analysis were used for testing differences between mean values. Odds ratio was used as a measure of association with a 95% confidence interval. RESULTS: The prevalence of PTB during the period of the study was 26% and the prevalence of CT among them was 13.9%. A total of 31.6% pregnant women were younger than 25 years old and women infected by CT were even younger than women not infected by CT (p = 0.022). Most of them (76.2%) were married or had a living partner, and CT infection was more frequent among the single ones (p = 0.018); 16.7% of women reported their first sexual intercourse under 14 years old. The causes of prematurity were maternal-fetal in 40.9%; rupture of the membranes in 29.7% and premature labor in 29.4%. In multivariate analysis, being married was a protective factor for infection [OR = 0.48 (95%CI:0.24–0.97)]. None of the other characteristics were associated with CT infection. CONCLUSIONS: This study shows a high prevalence of CT infection among parturient who have preterm birth. This high prevalence highlight the need for defining screening strategies focused on young pregnant women in Brazil. Public Library of Science 2015-10-27 /pmc/articles/PMC4624773/ /pubmed/26505892 http://dx.doi.org/10.1371/journal.pone.0141367 Text en © 2015 Schmidt et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Schmidt, Renylena Muniz, Renan Rosetti Cola, Elizandra Stauffert, Dulce Silveira, Mariangela Freitas Miranda, Angelica E. Maternal Chlamydia trachomatis Infections and Preterm Births in a University Hospital in Vitoria, Brazil |
title | Maternal Chlamydia trachomatis Infections and Preterm Births in a University Hospital in Vitoria, Brazil |
title_full | Maternal Chlamydia trachomatis Infections and Preterm Births in a University Hospital in Vitoria, Brazil |
title_fullStr | Maternal Chlamydia trachomatis Infections and Preterm Births in a University Hospital in Vitoria, Brazil |
title_full_unstemmed | Maternal Chlamydia trachomatis Infections and Preterm Births in a University Hospital in Vitoria, Brazil |
title_short | Maternal Chlamydia trachomatis Infections and Preterm Births in a University Hospital in Vitoria, Brazil |
title_sort | maternal chlamydia trachomatis infections and preterm births in a university hospital in vitoria, brazil |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624773/ https://www.ncbi.nlm.nih.gov/pubmed/26505892 http://dx.doi.org/10.1371/journal.pone.0141367 |
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