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TRIM21 Promotes cGAS and RIG-I Sensing of Viral Genomes during Infection by Antibody-Opsonized Virus

Encapsidation is a strategy almost universally employed by viruses to protect their genomes from degradation and from innate immune sensors. We show that TRIM21, which targets antibody-opsonized virions for proteasomal destruction, circumvents this protection, enabling the rapid detection and degrad...

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Detalles Bibliográficos
Autores principales:	Watkinson, Ruth E., McEwan, William A., Tam, Jerry C. H., Vaysburd, Marina, James, Leo C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624778/ https://www.ncbi.nlm.nih.gov/pubmed/26506431 http://dx.doi.org/10.1371/journal.ppat.1005253

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