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Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study
It has been hypothesized that the association between hypertension and gout is bidirectional, however, few studies have examined this in a prospective cohort. We analyzed data from the Singapore Chinese Health Study (SCHS) follow-up I (1999–2004) and II (2006–2010) interviews, when both physician-di...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624790/ https://www.ncbi.nlm.nih.gov/pubmed/26510154 http://dx.doi.org/10.1371/journal.pone.0141749 |
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author | Pan, An Teng, Gim Gee Yuan, Jian-Min Koh, Woon-Puay |
author_facet | Pan, An Teng, Gim Gee Yuan, Jian-Min Koh, Woon-Puay |
author_sort | Pan, An |
collection | PubMed |
description | It has been hypothesized that the association between hypertension and gout is bidirectional, however, few studies have examined this in a prospective cohort. We analyzed data from the Singapore Chinese Health Study (SCHS) follow-up I (1999–2004) and II (2006–2010) interviews, when both physician-diagnosed hypertension and gout were self-reported. We included participants with data for both follow-up interviews and who were free of heart disease, stroke and cancer at follow-up I. The analysis of hypertension and risk of gout included 31,137 participants when prevalent gout cases were excluded, while the analysis of gout and risk of hypertension included 20,369 participants when prevalent hypertension cases were excluded. Cox proportional hazards models were used to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). The mean age at follow-up I was 60.1 (SD 7.3) years, and the average follow-up was 6.8 (SD 1.4) years. In the analysis of hypertension and risk of gout, 682 incident cases were identified. Compared to normotensive participants, hypertensive patients had an88% increased risk of developing gout (HR 1.88; 95% CI 1.61–2.21). In the parallel analysis, 5,450 participants reported to have newly diagnosed hypertension during follow-up. Compared to participants without gout, those with gout had an18% increased risk of developing hypertension (HR 1.18; 95% CI 1.02–1.37). The bidirectional association was stronger in normal weight adults compared to overweight/obese individuals (P (interaction) = 0.06 and 0.04, respectively). The hypertension to gout association was stronger in women compared to men (P (interaction) = 0.04), while the gout to hypertension association was evident in women but not in men (P (interaction) = 0.02). In conclusion, our results suggest that the hypertension-gout association is bidirectional in this cohort of Singapore Chinese adults. The potential interactions of the bidirectional association with obesity and sex deserve further investigations. |
format | Online Article Text |
id | pubmed-4624790 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-46247902015-11-06 Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study Pan, An Teng, Gim Gee Yuan, Jian-Min Koh, Woon-Puay PLoS One Research Article It has been hypothesized that the association between hypertension and gout is bidirectional, however, few studies have examined this in a prospective cohort. We analyzed data from the Singapore Chinese Health Study (SCHS) follow-up I (1999–2004) and II (2006–2010) interviews, when both physician-diagnosed hypertension and gout were self-reported. We included participants with data for both follow-up interviews and who were free of heart disease, stroke and cancer at follow-up I. The analysis of hypertension and risk of gout included 31,137 participants when prevalent gout cases were excluded, while the analysis of gout and risk of hypertension included 20,369 participants when prevalent hypertension cases were excluded. Cox proportional hazards models were used to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). The mean age at follow-up I was 60.1 (SD 7.3) years, and the average follow-up was 6.8 (SD 1.4) years. In the analysis of hypertension and risk of gout, 682 incident cases were identified. Compared to normotensive participants, hypertensive patients had an88% increased risk of developing gout (HR 1.88; 95% CI 1.61–2.21). In the parallel analysis, 5,450 participants reported to have newly diagnosed hypertension during follow-up. Compared to participants without gout, those with gout had an18% increased risk of developing hypertension (HR 1.18; 95% CI 1.02–1.37). The bidirectional association was stronger in normal weight adults compared to overweight/obese individuals (P (interaction) = 0.06 and 0.04, respectively). The hypertension to gout association was stronger in women compared to men (P (interaction) = 0.04), while the gout to hypertension association was evident in women but not in men (P (interaction) = 0.02). In conclusion, our results suggest that the hypertension-gout association is bidirectional in this cohort of Singapore Chinese adults. The potential interactions of the bidirectional association with obesity and sex deserve further investigations. Public Library of Science 2015-10-28 /pmc/articles/PMC4624790/ /pubmed/26510154 http://dx.doi.org/10.1371/journal.pone.0141749 Text en © 2015 Pan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Pan, An Teng, Gim Gee Yuan, Jian-Min Koh, Woon-Puay Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study |
title | Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study |
title_full | Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study |
title_fullStr | Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study |
title_full_unstemmed | Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study |
title_short | Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study |
title_sort | bidirectional association between self-reported hypertension and gout: the singapore chinese health study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624790/ https://www.ncbi.nlm.nih.gov/pubmed/26510154 http://dx.doi.org/10.1371/journal.pone.0141749 |
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