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Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study

It has been hypothesized that the association between hypertension and gout is bidirectional, however, few studies have examined this in a prospective cohort. We analyzed data from the Singapore Chinese Health Study (SCHS) follow-up I (1999–2004) and II (2006–2010) interviews, when both physician-di...

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Autores principales: Pan, An, Teng, Gim Gee, Yuan, Jian-Min, Koh, Woon-Puay
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624790/
https://www.ncbi.nlm.nih.gov/pubmed/26510154
http://dx.doi.org/10.1371/journal.pone.0141749
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author Pan, An
Teng, Gim Gee
Yuan, Jian-Min
Koh, Woon-Puay
author_facet Pan, An
Teng, Gim Gee
Yuan, Jian-Min
Koh, Woon-Puay
author_sort Pan, An
collection PubMed
description It has been hypothesized that the association between hypertension and gout is bidirectional, however, few studies have examined this in a prospective cohort. We analyzed data from the Singapore Chinese Health Study (SCHS) follow-up I (1999–2004) and II (2006–2010) interviews, when both physician-diagnosed hypertension and gout were self-reported. We included participants with data for both follow-up interviews and who were free of heart disease, stroke and cancer at follow-up I. The analysis of hypertension and risk of gout included 31,137 participants when prevalent gout cases were excluded, while the analysis of gout and risk of hypertension included 20,369 participants when prevalent hypertension cases were excluded. Cox proportional hazards models were used to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). The mean age at follow-up I was 60.1 (SD 7.3) years, and the average follow-up was 6.8 (SD 1.4) years. In the analysis of hypertension and risk of gout, 682 incident cases were identified. Compared to normotensive participants, hypertensive patients had an88% increased risk of developing gout (HR 1.88; 95% CI 1.61–2.21). In the parallel analysis, 5,450 participants reported to have newly diagnosed hypertension during follow-up. Compared to participants without gout, those with gout had an18% increased risk of developing hypertension (HR 1.18; 95% CI 1.02–1.37). The bidirectional association was stronger in normal weight adults compared to overweight/obese individuals (P (interaction) = 0.06 and 0.04, respectively). The hypertension to gout association was stronger in women compared to men (P (interaction) = 0.04), while the gout to hypertension association was evident in women but not in men (P (interaction) = 0.02). In conclusion, our results suggest that the hypertension-gout association is bidirectional in this cohort of Singapore Chinese adults. The potential interactions of the bidirectional association with obesity and sex deserve further investigations.
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spelling pubmed-46247902015-11-06 Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study Pan, An Teng, Gim Gee Yuan, Jian-Min Koh, Woon-Puay PLoS One Research Article It has been hypothesized that the association between hypertension and gout is bidirectional, however, few studies have examined this in a prospective cohort. We analyzed data from the Singapore Chinese Health Study (SCHS) follow-up I (1999–2004) and II (2006–2010) interviews, when both physician-diagnosed hypertension and gout were self-reported. We included participants with data for both follow-up interviews and who were free of heart disease, stroke and cancer at follow-up I. The analysis of hypertension and risk of gout included 31,137 participants when prevalent gout cases were excluded, while the analysis of gout and risk of hypertension included 20,369 participants when prevalent hypertension cases were excluded. Cox proportional hazards models were used to estimate multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). The mean age at follow-up I was 60.1 (SD 7.3) years, and the average follow-up was 6.8 (SD 1.4) years. In the analysis of hypertension and risk of gout, 682 incident cases were identified. Compared to normotensive participants, hypertensive patients had an88% increased risk of developing gout (HR 1.88; 95% CI 1.61–2.21). In the parallel analysis, 5,450 participants reported to have newly diagnosed hypertension during follow-up. Compared to participants without gout, those with gout had an18% increased risk of developing hypertension (HR 1.18; 95% CI 1.02–1.37). The bidirectional association was stronger in normal weight adults compared to overweight/obese individuals (P (interaction) = 0.06 and 0.04, respectively). The hypertension to gout association was stronger in women compared to men (P (interaction) = 0.04), while the gout to hypertension association was evident in women but not in men (P (interaction) = 0.02). In conclusion, our results suggest that the hypertension-gout association is bidirectional in this cohort of Singapore Chinese adults. The potential interactions of the bidirectional association with obesity and sex deserve further investigations. Public Library of Science 2015-10-28 /pmc/articles/PMC4624790/ /pubmed/26510154 http://dx.doi.org/10.1371/journal.pone.0141749 Text en © 2015 Pan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Pan, An
Teng, Gim Gee
Yuan, Jian-Min
Koh, Woon-Puay
Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study
title Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study
title_full Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study
title_fullStr Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study
title_full_unstemmed Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study
title_short Bidirectional Association between Self-Reported Hypertension and Gout: The Singapore Chinese Health Study
title_sort bidirectional association between self-reported hypertension and gout: the singapore chinese health study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624790/
https://www.ncbi.nlm.nih.gov/pubmed/26510154
http://dx.doi.org/10.1371/journal.pone.0141749
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