Impact of Diverse Immune Evasion Mechanisms of Cancer Cells on T Cells Engaged by EpCAM/CD3-Bispecific Antibody Construct AMG 110

BACKGROUND: Bispecific T cell engager (BiTE(®)) are single-chain bispecific antibody constructs with dual specificity for CD3 on T cells and a surface antigen on target cells. They can elicit a polyclonal cytotoxic T cell response that is not restricted by T cell receptor (TCR) specificity, and surf...

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Detalles Bibliográficos
Autores principales: Deisting, Wibke, Raum, Tobias, Kufer, Peter, Baeuerle, Patrick A., Münz, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624873/
https://www.ncbi.nlm.nih.gov/pubmed/26510188
http://dx.doi.org/10.1371/journal.pone.0141669

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