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The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria

Objectives. Sickle cell anaemia (SCA) is one of the commonest genetic disorders in the world. It is characterized by anaemia, periodic attacks of thrombotic pain, and chronic systemic organ damage. Recent studies have suggested that individuals with SCA especially from developing countries are more...

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Autores principales: Sani, Musa A., Adewuyi, James O., Babatunde, Abiola S., Olawumi, Hannah O., Shittu, Rasaki O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624881/
https://www.ncbi.nlm.nih.gov/pubmed/26550015
http://dx.doi.org/10.1155/2015/386451
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author Sani, Musa A.
Adewuyi, James O.
Babatunde, Abiola S.
Olawumi, Hannah O.
Shittu, Rasaki O.
author_facet Sani, Musa A.
Adewuyi, James O.
Babatunde, Abiola S.
Olawumi, Hannah O.
Shittu, Rasaki O.
author_sort Sani, Musa A.
collection PubMed
description Objectives. Sickle cell anaemia (SCA) is one of the commonest genetic disorders in the world. It is characterized by anaemia, periodic attacks of thrombotic pain, and chronic systemic organ damage. Recent studies have suggested that individuals with SCA especially from developing countries are more likely to be iron deficient rather than have iron overload. The study aims to determine the iron status of SCA patients in Ilorin, Nigeria. Methods. A cross-sectional study of 45 SCA patients in steady state and 45 non-SCA controls was undertaken. FBC, blood film, sFC, sTfR, and sTfR/log sFC index were done on all subjects. Results. The mean patients' serum ferritin (589.33 ± 427.61 ng/mL) was significantly higher than the mean serum ferritin of the controls (184.53 ± 119.74 ng/mL). The mean serum transferrin receptor of the patients (4.24 ± 0.17 μg/mL) was higher than that of the controls (3.96 ± 0.17 μg/mL) (p = 0.290). The mean serum transferrin receptor (sTfR)/log serum ferritin index of the patients (1.65 ± 0.27 μg/mL) was significantly lower than that of the control (1.82 ± 0.18 μg/mL) (p = 0.031). Conclusion. Iron deficiency is uncommon in SCA patients and periodic monitoring of the haematological, biochemical, and clinical features for iron status in SCA patients is advised.
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spelling pubmed-46248812015-11-08 The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria Sani, Musa A. Adewuyi, James O. Babatunde, Abiola S. Olawumi, Hannah O. Shittu, Rasaki O. Adv Hematol Research Article Objectives. Sickle cell anaemia (SCA) is one of the commonest genetic disorders in the world. It is characterized by anaemia, periodic attacks of thrombotic pain, and chronic systemic organ damage. Recent studies have suggested that individuals with SCA especially from developing countries are more likely to be iron deficient rather than have iron overload. The study aims to determine the iron status of SCA patients in Ilorin, Nigeria. Methods. A cross-sectional study of 45 SCA patients in steady state and 45 non-SCA controls was undertaken. FBC, blood film, sFC, sTfR, and sTfR/log sFC index were done on all subjects. Results. The mean patients' serum ferritin (589.33 ± 427.61 ng/mL) was significantly higher than the mean serum ferritin of the controls (184.53 ± 119.74 ng/mL). The mean serum transferrin receptor of the patients (4.24 ± 0.17 μg/mL) was higher than that of the controls (3.96 ± 0.17 μg/mL) (p = 0.290). The mean serum transferrin receptor (sTfR)/log serum ferritin index of the patients (1.65 ± 0.27 μg/mL) was significantly lower than that of the control (1.82 ± 0.18 μg/mL) (p = 0.031). Conclusion. Iron deficiency is uncommon in SCA patients and periodic monitoring of the haematological, biochemical, and clinical features for iron status in SCA patients is advised. Hindawi Publishing Corporation 2015 2015-10-15 /pmc/articles/PMC4624881/ /pubmed/26550015 http://dx.doi.org/10.1155/2015/386451 Text en Copyright © 2015 Musa A. Sani et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sani, Musa A.
Adewuyi, James O.
Babatunde, Abiola S.
Olawumi, Hannah O.
Shittu, Rasaki O.
The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria
title The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria
title_full The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria
title_fullStr The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria
title_full_unstemmed The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria
title_short The Iron Status of Sickle Cell Anaemia Patients in Ilorin, North Central Nigeria
title_sort iron status of sickle cell anaemia patients in ilorin, north central nigeria
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624881/
https://www.ncbi.nlm.nih.gov/pubmed/26550015
http://dx.doi.org/10.1155/2015/386451
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