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Accumulation of the Vitamin D Precursor Cholecalciferol Antagonizes Hedgehog Signaling to Impair Hemogenic Endothelium Formation

Hematopoietic stem and progenitor cells (HSPCs) are born from hemogenic endothelium in the dorsal aorta. Specification of this hematopoietic niche is regulated by a signaling axis using Hedgehog (Hh) and Notch, which culminates in expression of Runx1 in the ventral wall of the artery. Here, we demon...

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Detalles Bibliográficos
Autores principales:	Cortes, Mauricio, Liu, Sarah Y., Kwan, Wanda, Alexa, Kristen, Goessling, Wolfram, North, Trista E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624955/ https://www.ncbi.nlm.nih.gov/pubmed/26365513 http://dx.doi.org/10.1016/j.stemcr.2015.08.010

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