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A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain

Neural stem cells in different locations of the postnatal mouse ventricular-subventricular zone (V-SVZ) generate different subtypes of olfactory bulb (OB) interneurons. High Sonic hedgehog (SHH) signaling in the ventral V-SVZ regulates the production of specific subtypes of neurons destined for the...

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Autores principales: Tong, Cheuk Ka, Fuentealba, Luis C., Shah, Jugal K., Lindquist, Robert A., Ihrie, Rebecca A., Guinto, Cristina D., Rodas-Rodriguez, Jose L., Alvarez-Buylla, Arturo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624995/
https://www.ncbi.nlm.nih.gov/pubmed/26411905
http://dx.doi.org/10.1016/j.stemcr.2015.08.013
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author Tong, Cheuk Ka
Fuentealba, Luis C.
Shah, Jugal K.
Lindquist, Robert A.
Ihrie, Rebecca A.
Guinto, Cristina D.
Rodas-Rodriguez, Jose L.
Alvarez-Buylla, Arturo
author_facet Tong, Cheuk Ka
Fuentealba, Luis C.
Shah, Jugal K.
Lindquist, Robert A.
Ihrie, Rebecca A.
Guinto, Cristina D.
Rodas-Rodriguez, Jose L.
Alvarez-Buylla, Arturo
author_sort Tong, Cheuk Ka
collection PubMed
description Neural stem cells in different locations of the postnatal mouse ventricular-subventricular zone (V-SVZ) generate different subtypes of olfactory bulb (OB) interneurons. High Sonic hedgehog (SHH) signaling in the ventral V-SVZ regulates the production of specific subtypes of neurons destined for the OB. Here we found a transient territory of high SHH signaling in the dorsal V-SVZ beneath the corpus callosum (CC). Using intersectional lineage tracing in neonates to label dorsal radial glial cells (RGCs) expressing the SHH target gene Gli1, we demonstrate that this region produces many CC cells in the oligodendroglial lineage and specific subtypes of neurons in the OB. The number of oligodendroglial cells generated correlated with the levels of SHH signaling. This work identifies a dorsal domain of SHH signaling, which is an important source of oligodendroglial cells for the postnatal mammalian forebrain.
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spelling pubmed-46249952015-11-19 A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain Tong, Cheuk Ka Fuentealba, Luis C. Shah, Jugal K. Lindquist, Robert A. Ihrie, Rebecca A. Guinto, Cristina D. Rodas-Rodriguez, Jose L. Alvarez-Buylla, Arturo Stem Cell Reports Report Neural stem cells in different locations of the postnatal mouse ventricular-subventricular zone (V-SVZ) generate different subtypes of olfactory bulb (OB) interneurons. High Sonic hedgehog (SHH) signaling in the ventral V-SVZ regulates the production of specific subtypes of neurons destined for the OB. Here we found a transient territory of high SHH signaling in the dorsal V-SVZ beneath the corpus callosum (CC). Using intersectional lineage tracing in neonates to label dorsal radial glial cells (RGCs) expressing the SHH target gene Gli1, we demonstrate that this region produces many CC cells in the oligodendroglial lineage and specific subtypes of neurons in the OB. The number of oligodendroglial cells generated correlated with the levels of SHH signaling. This work identifies a dorsal domain of SHH signaling, which is an important source of oligodendroglial cells for the postnatal mammalian forebrain. Elsevier 2015-09-24 /pmc/articles/PMC4624995/ /pubmed/26411905 http://dx.doi.org/10.1016/j.stemcr.2015.08.013 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Report
Tong, Cheuk Ka
Fuentealba, Luis C.
Shah, Jugal K.
Lindquist, Robert A.
Ihrie, Rebecca A.
Guinto, Cristina D.
Rodas-Rodriguez, Jose L.
Alvarez-Buylla, Arturo
A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain
title A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain
title_full A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain
title_fullStr A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain
title_full_unstemmed A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain
title_short A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain
title_sort dorsal shh-dependent domain in the v-svz produces large numbers of oligodendroglial lineage cells in the postnatal brain
topic Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624995/
https://www.ncbi.nlm.nih.gov/pubmed/26411905
http://dx.doi.org/10.1016/j.stemcr.2015.08.013
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