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A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain
Neural stem cells in different locations of the postnatal mouse ventricular-subventricular zone (V-SVZ) generate different subtypes of olfactory bulb (OB) interneurons. High Sonic hedgehog (SHH) signaling in the ventral V-SVZ regulates the production of specific subtypes of neurons destined for the...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624995/ https://www.ncbi.nlm.nih.gov/pubmed/26411905 http://dx.doi.org/10.1016/j.stemcr.2015.08.013 |
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author | Tong, Cheuk Ka Fuentealba, Luis C. Shah, Jugal K. Lindquist, Robert A. Ihrie, Rebecca A. Guinto, Cristina D. Rodas-Rodriguez, Jose L. Alvarez-Buylla, Arturo |
author_facet | Tong, Cheuk Ka Fuentealba, Luis C. Shah, Jugal K. Lindquist, Robert A. Ihrie, Rebecca A. Guinto, Cristina D. Rodas-Rodriguez, Jose L. Alvarez-Buylla, Arturo |
author_sort | Tong, Cheuk Ka |
collection | PubMed |
description | Neural stem cells in different locations of the postnatal mouse ventricular-subventricular zone (V-SVZ) generate different subtypes of olfactory bulb (OB) interneurons. High Sonic hedgehog (SHH) signaling in the ventral V-SVZ regulates the production of specific subtypes of neurons destined for the OB. Here we found a transient territory of high SHH signaling in the dorsal V-SVZ beneath the corpus callosum (CC). Using intersectional lineage tracing in neonates to label dorsal radial glial cells (RGCs) expressing the SHH target gene Gli1, we demonstrate that this region produces many CC cells in the oligodendroglial lineage and specific subtypes of neurons in the OB. The number of oligodendroglial cells generated correlated with the levels of SHH signaling. This work identifies a dorsal domain of SHH signaling, which is an important source of oligodendroglial cells for the postnatal mammalian forebrain. |
format | Online Article Text |
id | pubmed-4624995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-46249952015-11-19 A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain Tong, Cheuk Ka Fuentealba, Luis C. Shah, Jugal K. Lindquist, Robert A. Ihrie, Rebecca A. Guinto, Cristina D. Rodas-Rodriguez, Jose L. Alvarez-Buylla, Arturo Stem Cell Reports Report Neural stem cells in different locations of the postnatal mouse ventricular-subventricular zone (V-SVZ) generate different subtypes of olfactory bulb (OB) interneurons. High Sonic hedgehog (SHH) signaling in the ventral V-SVZ regulates the production of specific subtypes of neurons destined for the OB. Here we found a transient territory of high SHH signaling in the dorsal V-SVZ beneath the corpus callosum (CC). Using intersectional lineage tracing in neonates to label dorsal radial glial cells (RGCs) expressing the SHH target gene Gli1, we demonstrate that this region produces many CC cells in the oligodendroglial lineage and specific subtypes of neurons in the OB. The number of oligodendroglial cells generated correlated with the levels of SHH signaling. This work identifies a dorsal domain of SHH signaling, which is an important source of oligodendroglial cells for the postnatal mammalian forebrain. Elsevier 2015-09-24 /pmc/articles/PMC4624995/ /pubmed/26411905 http://dx.doi.org/10.1016/j.stemcr.2015.08.013 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Report Tong, Cheuk Ka Fuentealba, Luis C. Shah, Jugal K. Lindquist, Robert A. Ihrie, Rebecca A. Guinto, Cristina D. Rodas-Rodriguez, Jose L. Alvarez-Buylla, Arturo A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain |
title | A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain |
title_full | A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain |
title_fullStr | A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain |
title_full_unstemmed | A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain |
title_short | A Dorsal SHH-Dependent Domain in the V-SVZ Produces Large Numbers of Oligodendroglial Lineage Cells in the Postnatal Brain |
title_sort | dorsal shh-dependent domain in the v-svz produces large numbers of oligodendroglial lineage cells in the postnatal brain |
topic | Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624995/ https://www.ncbi.nlm.nih.gov/pubmed/26411905 http://dx.doi.org/10.1016/j.stemcr.2015.08.013 |
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