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OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus during Human ES Cell Differentiation into Definitive Endoderm

We demonstrate that the pluripotency gene OCT4 has a role in regulating differentiation via Wnt signaling. OCT4 expression levels in human embryonic stem cells increases transiently during the first 24 hr of in vitro differentiation, with OCT4 occupancy increasing at endoderm regulators such as SOX1...

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Detalles Bibliográficos
Autores principales:	Ying, Lei, Mills, Jason A., French, Deborah L., Gadue, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4624996/ https://www.ncbi.nlm.nih.gov/pubmed/26411902 http://dx.doi.org/10.1016/j.stemcr.2015.08.014

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