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In-Depth Characterization of Live Vaccines Used in Europe for Oral Rabies Vaccination of Wildlife

Although rabies incidence has fallen sharply over the past decades in Europe, the disease is still present in Eastern Europe. Oral rabies immunization of wild animal rabies has been shown to be the most effective method for the control and elimination of rabies. All rabies vaccines used in Europe ar...

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Autores principales: Cliquet, Florence, Picard-Meyer, Evelyne, Mojzis, Miroslav, Dirbakova, Zuzana, Muizniece, Zita, Jaceviciene, Ingrida, Mutinelli, Franco, Matulova, Marta, Frolichova, Jitka, Rychlik, Ivan, Celer, Vladimir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625003/
https://www.ncbi.nlm.nih.gov/pubmed/26509266
http://dx.doi.org/10.1371/journal.pone.0141537
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author Cliquet, Florence
Picard-Meyer, Evelyne
Mojzis, Miroslav
Dirbakova, Zuzana
Muizniece, Zita
Jaceviciene, Ingrida
Mutinelli, Franco
Matulova, Marta
Frolichova, Jitka
Rychlik, Ivan
Celer, Vladimir
author_facet Cliquet, Florence
Picard-Meyer, Evelyne
Mojzis, Miroslav
Dirbakova, Zuzana
Muizniece, Zita
Jaceviciene, Ingrida
Mutinelli, Franco
Matulova, Marta
Frolichova, Jitka
Rychlik, Ivan
Celer, Vladimir
author_sort Cliquet, Florence
collection PubMed
description Although rabies incidence has fallen sharply over the past decades in Europe, the disease is still present in Eastern Europe. Oral rabies immunization of wild animal rabies has been shown to be the most effective method for the control and elimination of rabies. All rabies vaccines used in Europe are modified live virus vaccines based on the Street Alabama Dufferin (SAD) strain isolated from a naturally-infected dog in 1935. Because of the potential safety risk of a live virus which could revert to virulence, the genetic composition of three commercial attenuated live rabies vaccines was investigated in two independent laboratories using next genome sequencing. This study is the first one reporting on the diversity of variants in oral rabies vaccines as well as the presence of a mix of at least two different variants in all tested batches. The results demonstrate the need for vaccine producers to use new robust methodologies in the context of their routine vaccine quality controls prior to market release.
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spelling pubmed-46250032015-11-06 In-Depth Characterization of Live Vaccines Used in Europe for Oral Rabies Vaccination of Wildlife Cliquet, Florence Picard-Meyer, Evelyne Mojzis, Miroslav Dirbakova, Zuzana Muizniece, Zita Jaceviciene, Ingrida Mutinelli, Franco Matulova, Marta Frolichova, Jitka Rychlik, Ivan Celer, Vladimir PLoS One Research Article Although rabies incidence has fallen sharply over the past decades in Europe, the disease is still present in Eastern Europe. Oral rabies immunization of wild animal rabies has been shown to be the most effective method for the control and elimination of rabies. All rabies vaccines used in Europe are modified live virus vaccines based on the Street Alabama Dufferin (SAD) strain isolated from a naturally-infected dog in 1935. Because of the potential safety risk of a live virus which could revert to virulence, the genetic composition of three commercial attenuated live rabies vaccines was investigated in two independent laboratories using next genome sequencing. This study is the first one reporting on the diversity of variants in oral rabies vaccines as well as the presence of a mix of at least two different variants in all tested batches. The results demonstrate the need for vaccine producers to use new robust methodologies in the context of their routine vaccine quality controls prior to market release. Public Library of Science 2015-10-28 /pmc/articles/PMC4625003/ /pubmed/26509266 http://dx.doi.org/10.1371/journal.pone.0141537 Text en © 2015 Cliquet et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Cliquet, Florence
Picard-Meyer, Evelyne
Mojzis, Miroslav
Dirbakova, Zuzana
Muizniece, Zita
Jaceviciene, Ingrida
Mutinelli, Franco
Matulova, Marta
Frolichova, Jitka
Rychlik, Ivan
Celer, Vladimir
In-Depth Characterization of Live Vaccines Used in Europe for Oral Rabies Vaccination of Wildlife
title In-Depth Characterization of Live Vaccines Used in Europe for Oral Rabies Vaccination of Wildlife
title_full In-Depth Characterization of Live Vaccines Used in Europe for Oral Rabies Vaccination of Wildlife
title_fullStr In-Depth Characterization of Live Vaccines Used in Europe for Oral Rabies Vaccination of Wildlife
title_full_unstemmed In-Depth Characterization of Live Vaccines Used in Europe for Oral Rabies Vaccination of Wildlife
title_short In-Depth Characterization of Live Vaccines Used in Europe for Oral Rabies Vaccination of Wildlife
title_sort in-depth characterization of live vaccines used in europe for oral rabies vaccination of wildlife
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625003/
https://www.ncbi.nlm.nih.gov/pubmed/26509266
http://dx.doi.org/10.1371/journal.pone.0141537
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