Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis

Enzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in Saccharopolyspora erythraea , the mutagenesis of DEBS and bioanalytical data on the experimental investigation of...

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Detalles Bibliográficos
Autores principales: Klopries, Stephan, Bravo-Rodriguez, Kenny, Koopmans, Kyra R.M., Sundermann, Uschi, Yahiaoui, Samir, Arens, Julia, Kushnir, Susanna, Sanchez-Garcia, Elsa, Schulz, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625040/
https://www.ncbi.nlm.nih.gov/pubmed/26587559
http://dx.doi.org/10.1016/j.dib.2015.09.052
Descripción
Sumario:Enzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in Saccharopolyspora erythraea , the mutagenesis of DEBS and bioanalytical data on the experimental investigation of studies on the biosynthetic pathway towards erythromycin are presented.

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