Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis

Enzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in Saccharopolyspora erythraea , the mutagenesis of DEBS and bioanalytical data on the experimental investigation of...

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Autores principales: Klopries, Stephan, Bravo-Rodriguez, Kenny, Koopmans, Kyra R.M., Sundermann, Uschi, Yahiaoui, Samir, Arens, Julia, Kushnir, Susanna, Sanchez-Garcia, Elsa, Schulz, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625040/
https://www.ncbi.nlm.nih.gov/pubmed/26587559
http://dx.doi.org/10.1016/j.dib.2015.09.052
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author Klopries, Stephan
Bravo-Rodriguez, Kenny
Koopmans, Kyra R.M.
Sundermann, Uschi
Yahiaoui, Samir
Arens, Julia
Kushnir, Susanna
Sanchez-Garcia, Elsa
Schulz, Frank
author_facet Klopries, Stephan
Bravo-Rodriguez, Kenny
Koopmans, Kyra R.M.
Sundermann, Uschi
Yahiaoui, Samir
Arens, Julia
Kushnir, Susanna
Sanchez-Garcia, Elsa
Schulz, Frank
author_sort Klopries, Stephan
collection PubMed
description Enzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in Saccharopolyspora erythraea , the mutagenesis of DEBS and bioanalytical data on the experimental investigation of studies on the biosynthetic pathway towards erythromycin are presented.
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spelling pubmed-46250402015-11-19 Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis Klopries, Stephan Bravo-Rodriguez, Kenny Koopmans, Kyra R.M. Sundermann, Uschi Yahiaoui, Samir Arens, Julia Kushnir, Susanna Sanchez-Garcia, Elsa Schulz, Frank Data Brief Data Article Enzyme-directed mutasynthesis is an emerging strategy for the targeted derivatization of natural products. Here, data on the synthesis of malonic acid derivatives for feeding studies in Saccharopolyspora erythraea , the mutagenesis of DEBS and bioanalytical data on the experimental investigation of studies on the biosynthetic pathway towards erythromycin are presented. Elsevier 2015-10-14 /pmc/articles/PMC4625040/ /pubmed/26587559 http://dx.doi.org/10.1016/j.dib.2015.09.052 Text en © 2015 Published by Elsevier Inc. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Klopries, Stephan
Bravo-Rodriguez, Kenny
Koopmans, Kyra R.M.
Sundermann, Uschi
Yahiaoui, Samir
Arens, Julia
Kushnir, Susanna
Sanchez-Garcia, Elsa
Schulz, Frank
Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
title Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
title_full Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
title_fullStr Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
title_full_unstemmed Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
title_short Data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
title_sort data in support of substrate flexibility of a mutated acyltransferase domain and implications for polyketide biosynthesis
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625040/
https://www.ncbi.nlm.nih.gov/pubmed/26587559
http://dx.doi.org/10.1016/j.dib.2015.09.052
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