Structural Studies of G Protein-Coupled Receptors

G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically important membrane protein family that recognizes a variety of environmental stimuli, and are drug targets in the treatment of numerous diseases. Recent progress on GPCR structural studies shed light on molecular...

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Detalles Bibliográficos
Autores principales: Zhang, Dandan, Zhao, Qiang, Wu, Beili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2015
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625064/
https://www.ncbi.nlm.nih.gov/pubmed/26467290
http://dx.doi.org/10.14348/molcells.2015.0263
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author Zhang, Dandan
Zhao, Qiang
Wu, Beili
author_facet Zhang, Dandan
Zhao, Qiang
Wu, Beili
author_sort Zhang, Dandan
collection PubMed
description G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically important membrane protein family that recognizes a variety of environmental stimuli, and are drug targets in the treatment of numerous diseases. Recent progress on GPCR structural studies shed light on molecular mechanisms of GPCR ligand recognition, activation and allosteric modulation, as well as structural basis of GPCR dimerization. In this review, we will discuss the structural features of GPCRs and structural insights of different aspects of GPCR biological functions.
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spelling pubmed-46250642015-11-03 Structural Studies of G Protein-Coupled Receptors Zhang, Dandan Zhao, Qiang Wu, Beili Mol Cells Minireview G protein-coupled receptors (GPCRs) constitute the largest and the most physiologically important membrane protein family that recognizes a variety of environmental stimuli, and are drug targets in the treatment of numerous diseases. Recent progress on GPCR structural studies shed light on molecular mechanisms of GPCR ligand recognition, activation and allosteric modulation, as well as structural basis of GPCR dimerization. In this review, we will discuss the structural features of GPCRs and structural insights of different aspects of GPCR biological functions. Korean Society for Molecular and Cellular Biology 2015-10-31 2015-10-15 /pmc/articles/PMC4625064/ /pubmed/26467290 http://dx.doi.org/10.14348/molcells.2015.0263 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.
spellingShingle Minireview
Zhang, Dandan
Zhao, Qiang
Wu, Beili
Structural Studies of G Protein-Coupled Receptors
title Structural Studies of G Protein-Coupled Receptors
title_full Structural Studies of G Protein-Coupled Receptors
title_fullStr Structural Studies of G Protein-Coupled Receptors
title_full_unstemmed Structural Studies of G Protein-Coupled Receptors
title_short Structural Studies of G Protein-Coupled Receptors
title_sort structural studies of g protein-coupled receptors
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625064/
https://www.ncbi.nlm.nih.gov/pubmed/26467290
http://dx.doi.org/10.14348/molcells.2015.0263
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