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Genetically engineered microorganisms for the detection of explosives’ residues

The manufacture and use of explosives throughout the past century has resulted in the extensive pollution of soils and groundwater, and the widespread interment of landmines imposes a major humanitarian risk and prevents civil development of large areas. As most current landmine detection technologi...

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Autores principales: Shemer, Benjamin, Palevsky, Noa, Yagur-Kroll, Sharon, Belkin, Shimshon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625088/
https://www.ncbi.nlm.nih.gov/pubmed/26579085
http://dx.doi.org/10.3389/fmicb.2015.01175
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author Shemer, Benjamin
Palevsky, Noa
Yagur-Kroll, Sharon
Belkin, Shimshon
author_facet Shemer, Benjamin
Palevsky, Noa
Yagur-Kroll, Sharon
Belkin, Shimshon
author_sort Shemer, Benjamin
collection PubMed
description The manufacture and use of explosives throughout the past century has resulted in the extensive pollution of soils and groundwater, and the widespread interment of landmines imposes a major humanitarian risk and prevents civil development of large areas. As most current landmine detection technologies require actual presence at the surveyed areas, thus posing a significant risk to personnel, diverse research efforts are aimed at the development of remote detection solutions. One possible means proposed to fulfill this objective is the use of microbial bioreporters: genetically engineered microorganisms “tailored” to generate an optical signal in the presence of explosives’ vapors. The use of such sensor bacteria will allow to pinpoint the locations of explosive devices in a minefield. While no study has yet resulted in a commercially operational system, significant progress has been made in the design and construction of explosives-sensing bacterial strains. In this article we review the attempts to construct microbial bioreporters for the detection of explosives, and analyze the steps that need to be undertaken for this strategy to be applicable for landmine detection.
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spelling pubmed-46250882015-11-17 Genetically engineered microorganisms for the detection of explosives’ residues Shemer, Benjamin Palevsky, Noa Yagur-Kroll, Sharon Belkin, Shimshon Front Microbiol Microbiology The manufacture and use of explosives throughout the past century has resulted in the extensive pollution of soils and groundwater, and the widespread interment of landmines imposes a major humanitarian risk and prevents civil development of large areas. As most current landmine detection technologies require actual presence at the surveyed areas, thus posing a significant risk to personnel, diverse research efforts are aimed at the development of remote detection solutions. One possible means proposed to fulfill this objective is the use of microbial bioreporters: genetically engineered microorganisms “tailored” to generate an optical signal in the presence of explosives’ vapors. The use of such sensor bacteria will allow to pinpoint the locations of explosive devices in a minefield. While no study has yet resulted in a commercially operational system, significant progress has been made in the design and construction of explosives-sensing bacterial strains. In this article we review the attempts to construct microbial bioreporters for the detection of explosives, and analyze the steps that need to be undertaken for this strategy to be applicable for landmine detection. Frontiers Media S.A. 2015-10-29 /pmc/articles/PMC4625088/ /pubmed/26579085 http://dx.doi.org/10.3389/fmicb.2015.01175 Text en Copyright © 2015 Shemer, Palevsky, Yagur-Kroll and Belkin. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Shemer, Benjamin
Palevsky, Noa
Yagur-Kroll, Sharon
Belkin, Shimshon
Genetically engineered microorganisms for the detection of explosives’ residues
title Genetically engineered microorganisms for the detection of explosives’ residues
title_full Genetically engineered microorganisms for the detection of explosives’ residues
title_fullStr Genetically engineered microorganisms for the detection of explosives’ residues
title_full_unstemmed Genetically engineered microorganisms for the detection of explosives’ residues
title_short Genetically engineered microorganisms for the detection of explosives’ residues
title_sort genetically engineered microorganisms for the detection of explosives’ residues
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625088/
https://www.ncbi.nlm.nih.gov/pubmed/26579085
http://dx.doi.org/10.3389/fmicb.2015.01175
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