Membrane–drug interactions studied using model membrane systems

The direct interaction of drugs with the cell membrane is often neglected when drug effects are studied. Systematic investigations are hindered by the complexity of the natural membrane and model membrane systems can offer a useful alternative. Here some examples are reviewed of how model membrane a...

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Detalles Bibliográficos
Autores principales: Knobloch, Jacqueline, Suhendro, Daniel K., Zieleniecki, Julius L., Shapter, Joseph G., Köper, Ingo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625119/
https://www.ncbi.nlm.nih.gov/pubmed/26586998
http://dx.doi.org/10.1016/j.sjbs.2015.03.007
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author Knobloch, Jacqueline
Suhendro, Daniel K.
Zieleniecki, Julius L.
Shapter, Joseph G.
Köper, Ingo
author_facet Knobloch, Jacqueline
Suhendro, Daniel K.
Zieleniecki, Julius L.
Shapter, Joseph G.
Köper, Ingo
author_sort Knobloch, Jacqueline
collection PubMed
description The direct interaction of drugs with the cell membrane is often neglected when drug effects are studied. Systematic investigations are hindered by the complexity of the natural membrane and model membrane systems can offer a useful alternative. Here some examples are reviewed of how model membrane architectures including vesicles, Langmuir monolayers and solid supported membranes can be used to investigate the effects of drug molecules on the membrane structure, and how these interactions can translate into effects on embedded membrane proteins.
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spelling pubmed-46251192015-11-19 Membrane–drug interactions studied using model membrane systems Knobloch, Jacqueline Suhendro, Daniel K. Zieleniecki, Julius L. Shapter, Joseph G. Köper, Ingo Saudi J Biol Sci Original Article The direct interaction of drugs with the cell membrane is often neglected when drug effects are studied. Systematic investigations are hindered by the complexity of the natural membrane and model membrane systems can offer a useful alternative. Here some examples are reviewed of how model membrane architectures including vesicles, Langmuir monolayers and solid supported membranes can be used to investigate the effects of drug molecules on the membrane structure, and how these interactions can translate into effects on embedded membrane proteins. Elsevier 2015-11 2015-03-24 /pmc/articles/PMC4625119/ /pubmed/26586998 http://dx.doi.org/10.1016/j.sjbs.2015.03.007 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Knobloch, Jacqueline
Suhendro, Daniel K.
Zieleniecki, Julius L.
Shapter, Joseph G.
Köper, Ingo
Membrane–drug interactions studied using model membrane systems
title Membrane–drug interactions studied using model membrane systems
title_full Membrane–drug interactions studied using model membrane systems
title_fullStr Membrane–drug interactions studied using model membrane systems
title_full_unstemmed Membrane–drug interactions studied using model membrane systems
title_short Membrane–drug interactions studied using model membrane systems
title_sort membrane–drug interactions studied using model membrane systems
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625119/
https://www.ncbi.nlm.nih.gov/pubmed/26586998
http://dx.doi.org/10.1016/j.sjbs.2015.03.007
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AT zielenieckijuliusl membranedruginteractionsstudiedusingmodelmembranesystems
AT shapterjosephg membranedruginteractionsstudiedusingmodelmembranesystems
AT koperingo membranedruginteractionsstudiedusingmodelmembranesystems

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