Cargando…

In vivo evidence for an endothelium-dependent mechanism in radiation-induced normal tissue injury

The pathophysiological mechanism involved in side effects of radiation therapy, and especially the role of the endothelium remains unclear. Previous results showed that plasminogen activator inhibitor-type 1 (PAI-1) contributes to radiation-induced intestinal injury and suggested that this role coul...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rannou, Emilie, François, Agnès, Toullec, Aurore, Guipaud, Olivier, Buard, Valérie, Tarlet, Georges, Mintet, Elodie, Jaillet, Cyprien, Iruela-Arispe, Maria Luisa, Benderitter, Marc, Sabourin, Jean-Christophe, Milliat, Fabien
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625166/ https://www.ncbi.nlm.nih.gov/pubmed/26510580 http://dx.doi.org/10.1038/srep15738

Ejemplares similares

HIF-1α Deletion in the Endothelium, but Not in the Epithelium, Protects From Radiation-Induced Enteritis
por: Toullec, Aurore, et al.
Publicado: (2017)

Endothelial Hey2 deletion reduces endothelial-to-mesenchymal transition and mitigates radiation proctitis in mice
por: Mintet, Elodie, et al.
Publicado: (2017)

Radiation-induced changes in the glycome of endothelial cells with functional consequences
por: Jaillet, Cyprien, et al.
Publicado: (2017)

PAI-1-Dependent Endothelial Cell Death Determines Severity of Radiation-Induced Intestinal Injury
por: Abderrahmani, Rym, et al.
Publicado: (2012)

Temporal clustering analysis of endothelial cell gene expression following exposure to a conventional radiotherapy dose fraction using Gaussian process clustering
por: Heinonen, Markus, et al.
Publicado: (2018)

Preclinical Model of Stereotactic Ablative Lung Irradiation Using Arc Delivery in the Mouse: Is Fractionation Worthwhile?
por: Bertho, Annaïg, et al.
Publicado: (2021)

The TGF-β/Smad Repressor TG-Interacting Factor 1 (TGIF1) Plays a Role in Radiation-Induced Intestinal Injury Independently of a Smad Signaling Pathway
por: Hneino, Mohammad, et al.
Publicado: (2012)

Inflammation and Immunity in Radiation Damage to the Gut Mucosa
por: François, Agnès, et al.
Publicado: (2013)

Multiparametric radiobiological assays show that variation of X-ray energy strongly impacts relative biological effectiveness: comparison between 220 kV and 4 MV
por: Paget, Vincent, et al.
Publicado: (2019)

A role for endothelial alpha-mannosidase MAN1C1 in radiation-induced immune cell recruitment
por: Ladaigue, Ségolène, et al.
Publicado: (2022)

Deep models of integrated multiscale molecular data decipher the endothelial cell response to ionizing radiation
por: Morilla, Ian, et al.
Publicado: (2021)

Variation of 4 MV X-ray dose rate strongly impacts biological response both in vitro and in vivo
por: Ben Kacem, M., et al.
Publicado: (2020)

Pumping blood with self-reliance and cooperation
por: Iruela-Arispe, M. Luisa
Publicado: (2018)

How to target vascular leakage in retinopathy: could a lipid tighten the pipes?
por: Iruela‐Arispe, M Luisa
Publicado: (2023)

Protocol for in vitro assessment of human monocyte transendothelial migration using a high-throughput live cell imaging system
por: Ladaigue, Ségolène, et al.
Publicado: (2023)

Mesenchymal stem cells limit vascular and epithelial damage and restore the impermeability of the urothelium in chronic radiation cystitis
por: Brossard, Clément, et al.
Publicado: (2023)

Nuclear Mechanosensation and Mechanotransduction in Vascular Cells
por: Salvador, Jocelynda, et al.
Publicado: (2022)

NOTCH regulation of the endothelial cell phenotype
por: Mack, Julia J., et al.
Publicado: (2018)

Mechanisms of Endothelial Regeneration and Vascular Repair and Their Application to Regenerative Medicine
por: Evans, Colin E., et al.
Publicado: (2021)

A Forward Genetic Screen Targeting the Endothelium Reveals a Regulatory Role for the Lipid Kinase Pi4ka in Myelo- and Erythropoiesis
por: Ziyad, Safiyyah, et al.
Publicado: (2018)

Understanding Molecular Mechanisms and Identifying Key Processes in Chronic Radiation Cystitis
por: Brossard, Clément, et al.
Publicado: (2022)

Early and Late Protective Effect of Bone Marrow Mononuclear Cell Transplantation on Radiation-Induced Vascular Dysfunction and Skin Lesions
por: Holler, Valérie, et al.
Publicado: (2018)

HGF and TSG-6 Released by Mesenchymal Stem Cells Attenuate Colon Radiation-Induced Fibrosis
por: Usunier, Benoît, et al.
Publicado: (2021)

Serum Proteome Analysis for Profiling Predictive Protein Markers Associated with the Severity of Skin Lesions Induced by Ionizing Radiation
por: Chaze, Thibault, et al.
Publicado: (2013)

Increased levels of type VIII collagen in human brain tumours compared to normal brain tissue and non-neoplastic cerebral disorders.
por: Paulus, W., et al.
Publicado: (1991)

The stromal vascular fraction mitigates radiation-induced gastrointestinal syndrome in mice
por: Bensemmane, Lydia, et al.
Publicado: (2021)

Molecular Mechanisms and Key Processes in Interstitial, Hemorrhagic and Radiation Cystitis
por: Brossard, Clément, et al.
Publicado: (2022)

Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors
por: Lee, Sunyoung, et al.
Publicado: (2005)

Selective Decline of Synaptic Protein Levels in the Frontal Cortex of Female Mice Deficient in the Extracellular Metalloproteinase ADAMTS1
por: Howell, Matthew D., et al.
Publicado: (2012)

Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells
por: Chen, Tom T., et al.
Publicado: (2010)

The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage
por: Lancrin, Christophe, et al.
Publicado: (2009)

Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2(Akita/+) Mice
por: Guihard, Pierre J., et al.
Publicado: (2016)

Recalibrating vascular malformations and mechanotransduction by pharmacological intervention
por: Abdelilah-Seyfried, Salim, et al.
Publicado: (2022)

A multi-step transcriptional cascade underlies vascular regeneration in vivo
por: Shirali, Aditya S., et al.
Publicado: (2018)

Regulation of RUNX1 dosage is crucial for efficient blood formation from hemogenic endothelium
por: Lie-A-Ling, Michael, et al.
Publicado: (2018)

Prophylactic Faecalibacterium prausnitzii treatment prevents the acute breakdown of colonic epithelial barrier in a preclinical model of pelvic radiation disease
por: Lapiere, Alexia, et al.
Publicado: (2020)

Relevance of the TRIAP1/p53 axis in colon cancer cell proliferation and adaptation to glutamine deprivation
por: Nedara, Kenza, et al.
Publicado: (2022)

Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro
por: Garcia-Alegria, Eva, et al.
Publicado: (2018)

HMGA2 immunostaining is a straightforward technique which helps to distinguish pulmonary fat-forming lesions from normal adipose tissue in small biopsies: a retrospective observational study about a series of 13 lung biopsies
por: Piton, Nicolas, et al.
Publicado: (2017)

Influence de la crise sanitaire COVID-19 sur la perception de la télérééducation dans la population des kinésithérapeutes français, une étude qualitative
por: Le Toullec, Elodie, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_khq3ciobmc7qaj8j77q6k9dt3l