Small airway epithelial-C/EBPβ is increased in patients with advanced COPD

The expression of CCAAT/enhancer-binding protein (C/EBP)β in the small airway epithelium of COPD is unknown. C/EBPβ was assessed in peripheral lung tissue of non-smoking/smoking controls and patients with GOLD I-IV COPD by quantitative immunohistochemistry. The expression of C/EBPβ was decreased in...

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Autores principales: Mori, Michiko, Bjermer, Leif, Erjefält, Jonas S., Stampfli, Martin R., Roos, Abraham B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625456/
https://www.ncbi.nlm.nih.gov/pubmed/26511475
http://dx.doi.org/10.1186/s12931-015-0297-0
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author Mori, Michiko
Bjermer, Leif
Erjefält, Jonas S.
Stampfli, Martin R.
Roos, Abraham B.
author_facet Mori, Michiko
Bjermer, Leif
Erjefält, Jonas S.
Stampfli, Martin R.
Roos, Abraham B.
author_sort Mori, Michiko
collection PubMed
description The expression of CCAAT/enhancer-binding protein (C/EBP)β in the small airway epithelium of COPD is unknown. C/EBPβ was assessed in peripheral lung tissue of non-smoking/smoking controls and patients with GOLD I-IV COPD by quantitative immunohistochemistry. The expression of C/EBPβ was decreased in smokers compared to never smokers. Furthermore, C/EBPβ was significantly elevated in advanced COPD vs. asymptomatic smokers, and the expression correlated to lung function decline. As C/EBPβ exerts pro-inflammatory effects in the context of cigarette smoke, the elevated C/EBPβ in advanced COPD may be an indication of a breakdown of regulatory mechanisms and excessive inflammation.
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spelling pubmed-46254562015-10-30 Small airway epithelial-C/EBPβ is increased in patients with advanced COPD Mori, Michiko Bjermer, Leif Erjefält, Jonas S. Stampfli, Martin R. Roos, Abraham B. Respir Res Letter to the Editor The expression of CCAAT/enhancer-binding protein (C/EBP)β in the small airway epithelium of COPD is unknown. C/EBPβ was assessed in peripheral lung tissue of non-smoking/smoking controls and patients with GOLD I-IV COPD by quantitative immunohistochemistry. The expression of C/EBPβ was decreased in smokers compared to never smokers. Furthermore, C/EBPβ was significantly elevated in advanced COPD vs. asymptomatic smokers, and the expression correlated to lung function decline. As C/EBPβ exerts pro-inflammatory effects in the context of cigarette smoke, the elevated C/EBPβ in advanced COPD may be an indication of a breakdown of regulatory mechanisms and excessive inflammation. BioMed Central 2015-10-29 2015 /pmc/articles/PMC4625456/ /pubmed/26511475 http://dx.doi.org/10.1186/s12931-015-0297-0 Text en © Mori et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Mori, Michiko
Bjermer, Leif
Erjefält, Jonas S.
Stampfli, Martin R.
Roos, Abraham B.
Small airway epithelial-C/EBPβ is increased in patients with advanced COPD
title Small airway epithelial-C/EBPβ is increased in patients with advanced COPD
title_full Small airway epithelial-C/EBPβ is increased in patients with advanced COPD
title_fullStr Small airway epithelial-C/EBPβ is increased in patients with advanced COPD
title_full_unstemmed Small airway epithelial-C/EBPβ is increased in patients with advanced COPD
title_short Small airway epithelial-C/EBPβ is increased in patients with advanced COPD
title_sort small airway epithelial-c/ebpβ is increased in patients with advanced copd
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625456/
https://www.ncbi.nlm.nih.gov/pubmed/26511475
http://dx.doi.org/10.1186/s12931-015-0297-0
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