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The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients

Recent advances in brain imaging have contributed to our understanding of the neural activity associated with acupuncture treatment. In this study, we investigated functional connectivity across longitudinal acupuncture treatments in older patients with knee osteoarthritis (OA). Over a period of 4 w...

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Autores principales: Chen, Xiaoyan, Spaeth, Rosa B., Freeman, Sonya G., Scarborough, Donna Moxley, Hashmi, Javeria A., Wey, Hsiao-Ying, Egorova, Natalia, Vangel, Mark, Mao, Jianren, Wasan, Ajay D., Edwards, Robert R., Gollub, Randy L., Kong, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625557/
https://www.ncbi.nlm.nih.gov/pubmed/26511911
http://dx.doi.org/10.1186/s12990-015-0071-9
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author Chen, Xiaoyan
Spaeth, Rosa B.
Freeman, Sonya G.
Scarborough, Donna Moxley
Hashmi, Javeria A.
Wey, Hsiao-Ying
Egorova, Natalia
Vangel, Mark
Mao, Jianren
Wasan, Ajay D.
Edwards, Robert R.
Gollub, Randy L.
Kong, Jian
author_facet Chen, Xiaoyan
Spaeth, Rosa B.
Freeman, Sonya G.
Scarborough, Donna Moxley
Hashmi, Javeria A.
Wey, Hsiao-Ying
Egorova, Natalia
Vangel, Mark
Mao, Jianren
Wasan, Ajay D.
Edwards, Robert R.
Gollub, Randy L.
Kong, Jian
author_sort Chen, Xiaoyan
collection PubMed
description Recent advances in brain imaging have contributed to our understanding of the neural activity associated with acupuncture treatment. In this study, we investigated functional connectivity across longitudinal acupuncture treatments in older patients with knee osteoarthritis (OA). Over a period of 4 weeks (six treatments), we collected resting state functional magnetic resonance imaging (fMRI) scans from 30 patients before and after their first, third and sixth treatments. Clinical outcome showed a significantly greater pain subscore on the Knee Injury and Osteoarthritis Outcome Score (KOOS) (indicative of improvement) with verum acupuncture than with sham acupuncture. Independent component analysis (ICA) of the resting state fMRI data showed that the right frontoparietal network (rFPN) and the executive control network (ECN) showed enhanced functional connectivity (FC) with the rostral anterior cingulate cortex/medial prefrontal cortex, a key region in the descending pain modulatory system, in the verum groups as compared to the sham group after treatments. We also found that the rFPN connectivity with the left insula is (1) significantly associated with changes in KOOS pain score after treatments, and (2) significantly enhanced after verum acupuncture treatments as compared to sham treatment. Analysis of the acupuncture needle stimulation scan showed that compared with sham treatment, verum acupuncture activated the left operculum/insula, which also overlaps with findings observed in resting state analysis. Our results suggest that acupuncture may achieve its therapeutic effect on knee OA pain by modulating functional connectivity between the rFPN, ECN and the descending pain modulatory pathway. Clinical trial number: NCT01079390 ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12990-015-0071-9) contains supplementary material, which is available to authorized users.
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spelling pubmed-46255572015-10-30 The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients Chen, Xiaoyan Spaeth, Rosa B. Freeman, Sonya G. Scarborough, Donna Moxley Hashmi, Javeria A. Wey, Hsiao-Ying Egorova, Natalia Vangel, Mark Mao, Jianren Wasan, Ajay D. Edwards, Robert R. Gollub, Randy L. Kong, Jian Mol Pain Research Recent advances in brain imaging have contributed to our understanding of the neural activity associated with acupuncture treatment. In this study, we investigated functional connectivity across longitudinal acupuncture treatments in older patients with knee osteoarthritis (OA). Over a period of 4 weeks (six treatments), we collected resting state functional magnetic resonance imaging (fMRI) scans from 30 patients before and after their first, third and sixth treatments. Clinical outcome showed a significantly greater pain subscore on the Knee Injury and Osteoarthritis Outcome Score (KOOS) (indicative of improvement) with verum acupuncture than with sham acupuncture. Independent component analysis (ICA) of the resting state fMRI data showed that the right frontoparietal network (rFPN) and the executive control network (ECN) showed enhanced functional connectivity (FC) with the rostral anterior cingulate cortex/medial prefrontal cortex, a key region in the descending pain modulatory system, in the verum groups as compared to the sham group after treatments. We also found that the rFPN connectivity with the left insula is (1) significantly associated with changes in KOOS pain score after treatments, and (2) significantly enhanced after verum acupuncture treatments as compared to sham treatment. Analysis of the acupuncture needle stimulation scan showed that compared with sham treatment, verum acupuncture activated the left operculum/insula, which also overlaps with findings observed in resting state analysis. Our results suggest that acupuncture may achieve its therapeutic effect on knee OA pain by modulating functional connectivity between the rFPN, ECN and the descending pain modulatory pathway. Clinical trial number: NCT01079390 ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12990-015-0071-9) contains supplementary material, which is available to authorized users. BioMed Central 2015-10-29 /pmc/articles/PMC4625557/ /pubmed/26511911 http://dx.doi.org/10.1186/s12990-015-0071-9 Text en © Chen et al. 2015 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Chen, Xiaoyan
Spaeth, Rosa B.
Freeman, Sonya G.
Scarborough, Donna Moxley
Hashmi, Javeria A.
Wey, Hsiao-Ying
Egorova, Natalia
Vangel, Mark
Mao, Jianren
Wasan, Ajay D.
Edwards, Robert R.
Gollub, Randy L.
Kong, Jian
The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients
title The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients
title_full The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients
title_fullStr The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients
title_full_unstemmed The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients
title_short The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients
title_sort modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625557/
https://www.ncbi.nlm.nih.gov/pubmed/26511911
http://dx.doi.org/10.1186/s12990-015-0071-9
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