A positive-negative mode of population covariation links brain connectivity, demographics and behavior

We investigated the relationship between individual subjects’ functional connectomes and 280 behavioral and demographic measures, in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of popula...

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Detalles Bibliográficos
Autores principales: Smith, Stephen, Nichols, Thomas, Vidaurre, Diego, Winkler, Anderson, Behrens, Timothy, Glasser, Matthew, Ugurbil, Kamil, Barch, Deanna, Van Essen, David, Miller, Karla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625579/
https://www.ncbi.nlm.nih.gov/pubmed/26414616
http://dx.doi.org/10.1038/nn.4125
Descripción
Sumario:We investigated the relationship between individual subjects’ functional connectomes and 280 behavioral and demographic measures, in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation; subjects were predominantly spread along a single “positive-negative” axis, linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.

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