A positive-negative mode of population covariation links brain connectivity, demographics and behavior

We investigated the relationship between individual subjects’ functional connectomes and 280 behavioral and demographic measures, in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of popula...

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Autores principales: Smith, Stephen, Nichols, Thomas, Vidaurre, Diego, Winkler, Anderson, Behrens, Timothy, Glasser, Matthew, Ugurbil, Kamil, Barch, Deanna, Van Essen, David, Miller, Karla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625579/
https://www.ncbi.nlm.nih.gov/pubmed/26414616
http://dx.doi.org/10.1038/nn.4125
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author Smith, Stephen
Nichols, Thomas
Vidaurre, Diego
Winkler, Anderson
Behrens, Timothy
Glasser, Matthew
Ugurbil, Kamil
Barch, Deanna
Van Essen, David
Miller, Karla
author_facet Smith, Stephen
Nichols, Thomas
Vidaurre, Diego
Winkler, Anderson
Behrens, Timothy
Glasser, Matthew
Ugurbil, Kamil
Barch, Deanna
Van Essen, David
Miller, Karla
author_sort Smith, Stephen
collection PubMed
description We investigated the relationship between individual subjects’ functional connectomes and 280 behavioral and demographic measures, in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation; subjects were predominantly spread along a single “positive-negative” axis, linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.
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spelling pubmed-46255792016-05-01 A positive-negative mode of population covariation links brain connectivity, demographics and behavior Smith, Stephen Nichols, Thomas Vidaurre, Diego Winkler, Anderson Behrens, Timothy Glasser, Matthew Ugurbil, Kamil Barch, Deanna Van Essen, David Miller, Karla Nat Neurosci Article We investigated the relationship between individual subjects’ functional connectomes and 280 behavioral and demographic measures, in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation; subjects were predominantly spread along a single “positive-negative” axis, linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity. 2015-09-28 2015-11 /pmc/articles/PMC4625579/ /pubmed/26414616 http://dx.doi.org/10.1038/nn.4125 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Smith, Stephen
Nichols, Thomas
Vidaurre, Diego
Winkler, Anderson
Behrens, Timothy
Glasser, Matthew
Ugurbil, Kamil
Barch, Deanna
Van Essen, David
Miller, Karla
A positive-negative mode of population covariation links brain connectivity, demographics and behavior
title A positive-negative mode of population covariation links brain connectivity, demographics and behavior
title_full A positive-negative mode of population covariation links brain connectivity, demographics and behavior
title_fullStr A positive-negative mode of population covariation links brain connectivity, demographics and behavior
title_full_unstemmed A positive-negative mode of population covariation links brain connectivity, demographics and behavior
title_short A positive-negative mode of population covariation links brain connectivity, demographics and behavior
title_sort positive-negative mode of population covariation links brain connectivity, demographics and behavior
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625579/
https://www.ncbi.nlm.nih.gov/pubmed/26414616
http://dx.doi.org/10.1038/nn.4125
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