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Interaction between HSP 70 and iNOS in skeletal muscle injury and repair

Muscle injuries are frequently occurred in various sports. The biological process and mechanism of muscle repair after injury are well known through the many studies. This study aimed at presenting heat shock protein and nitric oxide synthase are to respond to muscle damage and repair. This section...

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Autor principal: Kim, Kijeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Exercise Rehabilitation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625650/
https://www.ncbi.nlm.nih.gov/pubmed/26535212
http://dx.doi.org/10.12965/jer.150235
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author Kim, Kijeong
author_facet Kim, Kijeong
author_sort Kim, Kijeong
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description Muscle injuries are frequently occurred in various sports. The biological process and mechanism of muscle repair after injury are well known through the many studies. This study aimed at presenting heat shock protein and nitric oxide synthase are to respond to muscle damage and repair. This section discusses the results obtained through many articles. Heat shock proteins (HSPs) are considered to play an essential role in protecting cells from damage, preparing them to survive on new environmental challenges. In addition, exercise-induced changes such as heat shock, oxidative, metabolic, muscular, and cytokine stress seem to be responsible for the HSP response to exercise. Also, inducible nitric oxide synthase (iNOS) generates nitric oxide (NO) for prolonged period and causes pathophysiological effects. Furthermore, iNOS is involved in processes such as cell injury, wound repair, embryogenesis, tissue differentiation, and suppression of tumorigenesis. In conclusion, the inhibition of HSP 70 on caspase-3 and apoptosis is associated with its inhibition on iNOS that leads to less NO production.
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spelling pubmed-46256502015-11-03 Interaction between HSP 70 and iNOS in skeletal muscle injury and repair Kim, Kijeong J Exerc Rehabil Review Article Muscle injuries are frequently occurred in various sports. The biological process and mechanism of muscle repair after injury are well known through the many studies. This study aimed at presenting heat shock protein and nitric oxide synthase are to respond to muscle damage and repair. This section discusses the results obtained through many articles. Heat shock proteins (HSPs) are considered to play an essential role in protecting cells from damage, preparing them to survive on new environmental challenges. In addition, exercise-induced changes such as heat shock, oxidative, metabolic, muscular, and cytokine stress seem to be responsible for the HSP response to exercise. Also, inducible nitric oxide synthase (iNOS) generates nitric oxide (NO) for prolonged period and causes pathophysiological effects. Furthermore, iNOS is involved in processes such as cell injury, wound repair, embryogenesis, tissue differentiation, and suppression of tumorigenesis. In conclusion, the inhibition of HSP 70 on caspase-3 and apoptosis is associated with its inhibition on iNOS that leads to less NO production. Korean Society of Exercise Rehabilitation 2015-10-30 /pmc/articles/PMC4625650/ /pubmed/26535212 http://dx.doi.org/10.12965/jer.150235 Text en Copyright © 2015 Korean Society of Exercise Rehabilitation This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Kim, Kijeong
Interaction between HSP 70 and iNOS in skeletal muscle injury and repair
title Interaction between HSP 70 and iNOS in skeletal muscle injury and repair
title_full Interaction between HSP 70 and iNOS in skeletal muscle injury and repair
title_fullStr Interaction between HSP 70 and iNOS in skeletal muscle injury and repair
title_full_unstemmed Interaction between HSP 70 and iNOS in skeletal muscle injury and repair
title_short Interaction between HSP 70 and iNOS in skeletal muscle injury and repair
title_sort interaction between hsp 70 and inos in skeletal muscle injury and repair
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625650/
https://www.ncbi.nlm.nih.gov/pubmed/26535212
http://dx.doi.org/10.12965/jer.150235
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