Changes in the Expression and Distribution of Claudins, Increased Epithelial Apoptosis, and a Mannan-Binding Lectin-Associated Immune Response Lead to Barrier Dysfunction in Dextran Sodium Sulfate-Induced Rat Colitis

BACKGROUND/AIMS: This animal study aimed to define the underlying cellular mechanisms of intestinal barrier dysfunction. METHODS: Rats were fed 4% with dextran sodium sulfate (DSS) to induce experimental colitis. We analyzed the sugars in 24-hour urine output by high pressure liquid chromatography....

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Detalles Bibliográficos
Autores principales: Yuan, Bosi, Zhou, Shuping, Lu, Youke, Liu, Jiong, Jin, Xinxin, Wan, Haijun, Wang, Fangyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Office of Gut and Liver 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625702/
https://www.ncbi.nlm.nih.gov/pubmed/25717051
http://dx.doi.org/10.5009/gnl14155

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