Establishing Good Practices for Exposure–Response Analysis of Clinical Endpoints in Drug Development

This tutorial aims at promoting good practices for exposure–response (E-R) analyses of clinical endpoints in drug development. The focus is on practical aspects of E-R analyses to assist modeling scientists with a process of performing such analyses in a consistent manner across individuals and proj...

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Detalles Bibliográficos
Autores principales: Overgaard, RV, Ingwersen, SH, Tornøe, CW
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Tutorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625861/
https://www.ncbi.nlm.nih.gov/pubmed/26535157
http://dx.doi.org/10.1002/psp4.12015
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author Overgaard, RV
Ingwersen, SH
Tornøe, CW
author_facet Overgaard, RV
Ingwersen, SH
Tornøe, CW
author_sort Overgaard, RV
collection PubMed
description This tutorial aims at promoting good practices for exposure–response (E-R) analyses of clinical endpoints in drug development. The focus is on practical aspects of E-R analyses to assist modeling scientists with a process of performing such analyses in a consistent manner across individuals and projects and tailored to typical clinical drug development decisions. This includes general considerations for planning, conducting, and visualizing E-R analyses, and how these are linked to key questions.
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spelling pubmed-46258612015-11-03 Establishing Good Practices for Exposure–Response Analysis of Clinical Endpoints in Drug Development Overgaard, RV Ingwersen, SH Tornøe, CW CPT Pharmacometrics Syst Pharmacol Tutorial This tutorial aims at promoting good practices for exposure–response (E-R) analyses of clinical endpoints in drug development. The focus is on practical aspects of E-R analyses to assist modeling scientists with a process of performing such analyses in a consistent manner across individuals and projects and tailored to typical clinical drug development decisions. This includes general considerations for planning, conducting, and visualizing E-R analyses, and how these are linked to key questions. John Wiley & Sons, Ltd 2015-10 2015-09-22 /pmc/articles/PMC4625861/ /pubmed/26535157 http://dx.doi.org/10.1002/psp4.12015 Text en © 2015 The Authors CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Tutorial
Overgaard, RV
Ingwersen, SH
Tornøe, CW
Establishing Good Practices for Exposure–Response Analysis of Clinical Endpoints in Drug Development
title Establishing Good Practices for Exposure–Response Analysis of Clinical Endpoints in Drug Development
title_full Establishing Good Practices for Exposure–Response Analysis of Clinical Endpoints in Drug Development
title_fullStr Establishing Good Practices for Exposure–Response Analysis of Clinical Endpoints in Drug Development
title_full_unstemmed Establishing Good Practices for Exposure–Response Analysis of Clinical Endpoints in Drug Development
title_short Establishing Good Practices for Exposure–Response Analysis of Clinical Endpoints in Drug Development
title_sort establishing good practices for exposure–response analysis of clinical endpoints in drug development
topic Tutorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625861/
https://www.ncbi.nlm.nih.gov/pubmed/26535157
http://dx.doi.org/10.1002/psp4.12015
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