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Relating Chemical Structure to Cellular Response: An Integrative Analysis of Gene Expression, Bioactivity, and Structural Data Across 11,000 Compounds

A central premise in systems pharmacology is that structurally similar compounds have similar cellular responses; however, this principle often does not hold. One of the most widely used measures of cellular response is gene expression. By integrating gene expression data from Library of Integrated...

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Detalles Bibliográficos
Autores principales:	Chen, B, Greenside, P, Paik, H, Sirota, M, Hadley, D, Butte, AJ
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625862/ https://www.ncbi.nlm.nih.gov/pubmed/26535158 http://dx.doi.org/10.1002/psp4.12009

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