LSD1n is a H4K20 demethylase regulating memory formation via transcriptional elongation control

We report that a neuron-specific isoform of LSD1, LSD1n, resulting from an alternative splicing event, acquires a novel substrate specificity targeting histone H4 K20 methylation, both in vitro and in vivo. Selective genetic ablation of LSD1n leads to deficits in spatial learning and memory, reveali...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jianxun, Telese, Francesca, Tan, Yuliang, Li, Wenbo, Jin, Chunyu, He, Xin, Basnet, Harihar, Ma, Qi, Merkurjev, Daria, Zhu, Xiaoyan, Liu, Zhijie, Zhang, Jie, Ohgi, Kenny, Taylor, Havilah, White, Ryan R., Macfarlan, Todd S., Pfaff, Samuel L., Rosenfeld, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4625987/
https://www.ncbi.nlm.nih.gov/pubmed/26214369
http://dx.doi.org/10.1038/nn.4069

Ejemplares similares

Ejemplares similares