Mixed Phenotype Acute Leukemia with Low Hypodiploidy in a Pediatric Patient

We describe the case of a 16 year-old female with mixed phenotype acute leukemia B/myeloid, NOS (formerly biphenotypic leukemia) with masked hypodiploidy and somatic TP53 and CDKN2A/B deletions. She achieved morphologic remission with lymphoid-directed multi-agent chemotherapy, but experienced an ea...

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Autores principales: Salazar, Elizabeth G., Wertheim, Gerald B., Biegel, Jaclyn A., Hwang, William, Tasian, Sarah K., Rheingold, Susan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626005/
https://www.ncbi.nlm.nih.gov/pubmed/26525596
http://dx.doi.org/10.14205/2309-3021.2015.03.01.4
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author Salazar, Elizabeth G.
Wertheim, Gerald B.
Biegel, Jaclyn A.
Hwang, William
Tasian, Sarah K.
Rheingold, Susan R.
author_facet Salazar, Elizabeth G.
Wertheim, Gerald B.
Biegel, Jaclyn A.
Hwang, William
Tasian, Sarah K.
Rheingold, Susan R.
author_sort Salazar, Elizabeth G.
collection PubMed
description We describe the case of a 16 year-old female with mixed phenotype acute leukemia B/myeloid, NOS (formerly biphenotypic leukemia) with masked hypodiploidy and somatic TP53 and CDKN2A/B deletions. She achieved morphologic remission with lymphoid-directed multi-agent chemotherapy, but experienced an early medullary relapse 11 months from initial diagnosis. Her case details the unusual finding of hypodiploidy in a patient with ambiguous lineage leukemia and highlights the complexity of therapy selection for these high-risk patients.
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spelling pubmed-46260052015-10-29 Mixed Phenotype Acute Leukemia with Low Hypodiploidy in a Pediatric Patient Salazar, Elizabeth G. Wertheim, Gerald B. Biegel, Jaclyn A. Hwang, William Tasian, Sarah K. Rheingold, Susan R. J Pediatr Oncol Article We describe the case of a 16 year-old female with mixed phenotype acute leukemia B/myeloid, NOS (formerly biphenotypic leukemia) with masked hypodiploidy and somatic TP53 and CDKN2A/B deletions. She achieved morphologic remission with lymphoid-directed multi-agent chemotherapy, but experienced an early medullary relapse 11 months from initial diagnosis. Her case details the unusual finding of hypodiploidy in a patient with ambiguous lineage leukemia and highlights the complexity of therapy selection for these high-risk patients. 2015-03-25 2015 /pmc/articles/PMC4626005/ /pubmed/26525596 http://dx.doi.org/10.14205/2309-3021.2015.03.01.4 Text en This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Salazar, Elizabeth G.
Wertheim, Gerald B.
Biegel, Jaclyn A.
Hwang, William
Tasian, Sarah K.
Rheingold, Susan R.
Mixed Phenotype Acute Leukemia with Low Hypodiploidy in a Pediatric Patient
title Mixed Phenotype Acute Leukemia with Low Hypodiploidy in a Pediatric Patient
title_full Mixed Phenotype Acute Leukemia with Low Hypodiploidy in a Pediatric Patient
title_fullStr Mixed Phenotype Acute Leukemia with Low Hypodiploidy in a Pediatric Patient
title_full_unstemmed Mixed Phenotype Acute Leukemia with Low Hypodiploidy in a Pediatric Patient
title_short Mixed Phenotype Acute Leukemia with Low Hypodiploidy in a Pediatric Patient
title_sort mixed phenotype acute leukemia with low hypodiploidy in a pediatric patient
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626005/
https://www.ncbi.nlm.nih.gov/pubmed/26525596
http://dx.doi.org/10.14205/2309-3021.2015.03.01.4
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