Isoflurane suppresses the self-renewal of normal mouse neural stem cells in a p53-dependent manner by activating the Lkb1-p53-p21 signalling pathway

Isoflurane is widely used in anaesthesia for surgical operations. However, whether it elicits unwanted side effects, particularly in neuronal cells, remains to be fully elucidated. The Lkb1-p53-p21 signalling pathway is able to modulate neuronal self-renewal and proliferation. Furthermore, the suppr...

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Detalles Bibliográficos
Autores principales: HOU, LENGCHEN, LIU, TE, WANG, JIAN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626134/
https://www.ncbi.nlm.nih.gov/pubmed/26459766
http://dx.doi.org/10.3892/mmr.2015.4387

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626134/
https://www.ncbi.nlm.nih.gov/pubmed/26459766
http://dx.doi.org/10.3892/mmr.2015.4387

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