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OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats
In the pathophysiology of diabetic retinopathy (DR), advanced glycation end products (AGEs) and vascular endothelial growth factor (VEGF) are thought to have important roles. It is known that VEGF causes a breakdown of the blood-retinal barrier (BRB) and retinal neovascularization; however, how AGEs...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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D.A. Spandidos
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626176/ https://www.ncbi.nlm.nih.gov/pubmed/26460071 http://dx.doi.org/10.3892/mmr.2015.4413 |
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author | KIM, CHAN-SIK KIM, JUNGHYUN JO, KYUHYUNG LEE, YUN MI SOHN, EUNJIN YOO, NAM HEE KIM, JIN SOOK |
author_facet | KIM, CHAN-SIK KIM, JUNGHYUN JO, KYUHYUNG LEE, YUN MI SOHN, EUNJIN YOO, NAM HEE KIM, JIN SOOK |
author_sort | KIM, CHAN-SIK |
collection | PubMed |
description | In the pathophysiology of diabetic retinopathy (DR), advanced glycation end products (AGEs) and vascular endothelial growth factor (VEGF) are thought to have important roles. It is known that VEGF causes a breakdown of the blood-retinal barrier (BRB) and retinal neovascularization; however, how AGEs affect the retina has largely remained elusive. OSSC1E-K19 is a novel phytochemical component of Osteomeles schwerinae. The objective of the present study was to evaluate the protective effects of OSSC1E-K19 on retinal vascular injury in AGE-modified rat serum albumin (AGE-RSA)-induced retinopathy. AGE-RSA-injected rat eyes were used investigate the protective effects of OSSC1E-K19 on BRB breakdown. Intravitreal injection of OSSC1E-K19 prevented AGE-RSA-induced BRB breakdown and decreased retinal VEGF expression in retinal vessels. In addition, OSSC1E-K19 inhibited the loss of occludin, a significant tight junction protein. These results supported the potential therapeutic utility of OSSC1E-K19 for retinal vascular permeability diseases. |
format | Online Article Text |
id | pubmed-4626176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-46261762016-02-23 OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats KIM, CHAN-SIK KIM, JUNGHYUN JO, KYUHYUNG LEE, YUN MI SOHN, EUNJIN YOO, NAM HEE KIM, JIN SOOK Mol Med Rep Articles In the pathophysiology of diabetic retinopathy (DR), advanced glycation end products (AGEs) and vascular endothelial growth factor (VEGF) are thought to have important roles. It is known that VEGF causes a breakdown of the blood-retinal barrier (BRB) and retinal neovascularization; however, how AGEs affect the retina has largely remained elusive. OSSC1E-K19 is a novel phytochemical component of Osteomeles schwerinae. The objective of the present study was to evaluate the protective effects of OSSC1E-K19 on retinal vascular injury in AGE-modified rat serum albumin (AGE-RSA)-induced retinopathy. AGE-RSA-injected rat eyes were used investigate the protective effects of OSSC1E-K19 on BRB breakdown. Intravitreal injection of OSSC1E-K19 prevented AGE-RSA-induced BRB breakdown and decreased retinal VEGF expression in retinal vessels. In addition, OSSC1E-K19 inhibited the loss of occludin, a significant tight junction protein. These results supported the potential therapeutic utility of OSSC1E-K19 for retinal vascular permeability diseases. D.A. Spandidos 2015-11 2015-10-01 /pmc/articles/PMC4626176/ /pubmed/26460071 http://dx.doi.org/10.3892/mmr.2015.4413 Text en Copyright: © Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Articles KIM, CHAN-SIK KIM, JUNGHYUN JO, KYUHYUNG LEE, YUN MI SOHN, EUNJIN YOO, NAM HEE KIM, JIN SOOK OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats |
title | OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats |
title_full | OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats |
title_fullStr | OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats |
title_full_unstemmed | OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats |
title_short | OSSC1E-K19, a novel phytochemical component of Osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats |
title_sort | ossc1e-k19, a novel phytochemical component of osteomeles schwerinae, prevents glycated albumin-induced retinal vascular injury in rats |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626176/ https://www.ncbi.nlm.nih.gov/pubmed/26460071 http://dx.doi.org/10.3892/mmr.2015.4413 |
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