Characterization and Pharmacologic Targeting of EZH2, a Fetal Retinal Protein and Epigenetic Regulator, in Human Retinoblastoma

Retinoblastoma (RB) is the most common primary intraocular cancer in children, a nd the third most common cancer overall in infants. No molecular-targeted therapy for this lethal tumor exists. Since the tumor suppressor RB1, whose genetic inactivation underlies RB, is upstream of the epigenetic regu...

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Detalles Bibliográficos
Autores principales: Khan, Mehnaz, Walters, Laura L., Li, Qiang, Thomas, Dafydd G., Miller, Jason M.L., Zhang, Qitao, Sciallis, Andrew P., Liu, Yu, Dlouhy, Brian J., Fort, Patrice E., Archer, Steven M., Demirci, Hakan, Dou, Yali, Rao, Rajesh C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626270/
https://www.ncbi.nlm.nih.gov/pubmed/26280220
http://dx.doi.org/10.1038/labinvest.2015.104

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