Cargando…
Partitioning heritability by functional annotation using genome-wide association summary statistics
Recent work has demonstrated that some functional categories of the genome contribute disproportionately to the heritability of complex diseases. Here, we analyze a broad set of functional elements, including cell-type-specific elements, to estimate their polygenic contributions to heritability in g...
Autores principales: | Finucane, Hilary K., Bulik-Sullivan, Brendan, Gusev, Alexander, Trynka, Gosia, Reshef, Yakir, Loh, Po-Ru, Anttila, Verneri, Xu, Han, Zang, Chongzhi, Farh, Kyle, Ripke, Stephan, Day, Felix R., Consortium, ReproGen, Purcell, Shaun, Stahl, Eli, Lindstrom, Sara, Perry, John R. B., Okada, Yukinori, Raychaudhuri, Soumya, Daly, Mark, Patterson, Nick, Neale, Benjamin M., Price, Alkes L. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626285/ https://www.ncbi.nlm.nih.gov/pubmed/26414678 http://dx.doi.org/10.1038/ng.3404 |
Ejemplares similares
-
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
por: Finucane, Hilary K., et al.
Publicado: (2018) -
An Atlas of Genetic Correlations across Human Diseases and Traits
por: Bulik-Sullivan, Brendan, et al.
Publicado: (2015) -
Functionally-informed fine-mapping and polygenic localization of complex trait heritability
por: Weissbrod, Omer, et al.
Publicado: (2020) -
Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations
por: Luo, Yang, et al.
Publicado: (2021) -
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis
por: Zheng, Jie, et al.
Publicado: (2017)