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Prefrontal-amygdala fear networks come into focus
The ability to form associations between aversive threats and their predictors is fundamental to survival. However, fear and anxiety in excess are detrimental and are a hallmark of psychiatric diseases such as post-traumatic stress disorder (PTSD). PTSD symptomatology includes persistent and intrusi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626554/ https://www.ncbi.nlm.nih.gov/pubmed/26578902 http://dx.doi.org/10.3389/fnsys.2015.00145 |
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author | Arruda-Carvalho, Maithe Clem, Roger L. |
author_facet | Arruda-Carvalho, Maithe Clem, Roger L. |
author_sort | Arruda-Carvalho, Maithe |
collection | PubMed |
description | The ability to form associations between aversive threats and their predictors is fundamental to survival. However, fear and anxiety in excess are detrimental and are a hallmark of psychiatric diseases such as post-traumatic stress disorder (PTSD). PTSD symptomatology includes persistent and intrusive thoughts of an experienced trauma, suggesting an inability to downregulate fear when a corresponding threat has subsided. Convergent evidence from human and rodent studies supports a role for the medial prefrontal cortex (mPFC)-amygdala network in both PTSD and the regulation of fear memory expression. In particular, current models stipulate that the prelimbic (PL) and infralimbic (IL) subdivisions of the rodent mPFC bidirectionally regulate fear expression via differential recruitment of amygdala neuronal subpopulations. However, an array of recent studies that employ new technical approaches has fundamentally challenged this interpretation. Here we explore how a new emphasis on the contribution of inhibitory neuronal populations, subcortical structures and the passage of time is reshaping our understanding of mPFC-amygdala circuits and their control over fear. |
format | Online Article Text |
id | pubmed-4626554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-46265542015-11-17 Prefrontal-amygdala fear networks come into focus Arruda-Carvalho, Maithe Clem, Roger L. Front Syst Neurosci Neuroscience The ability to form associations between aversive threats and their predictors is fundamental to survival. However, fear and anxiety in excess are detrimental and are a hallmark of psychiatric diseases such as post-traumatic stress disorder (PTSD). PTSD symptomatology includes persistent and intrusive thoughts of an experienced trauma, suggesting an inability to downregulate fear when a corresponding threat has subsided. Convergent evidence from human and rodent studies supports a role for the medial prefrontal cortex (mPFC)-amygdala network in both PTSD and the regulation of fear memory expression. In particular, current models stipulate that the prelimbic (PL) and infralimbic (IL) subdivisions of the rodent mPFC bidirectionally regulate fear expression via differential recruitment of amygdala neuronal subpopulations. However, an array of recent studies that employ new technical approaches has fundamentally challenged this interpretation. Here we explore how a new emphasis on the contribution of inhibitory neuronal populations, subcortical structures and the passage of time is reshaping our understanding of mPFC-amygdala circuits and their control over fear. Frontiers Media S.A. 2015-10-30 /pmc/articles/PMC4626554/ /pubmed/26578902 http://dx.doi.org/10.3389/fnsys.2015.00145 Text en Copyright © 2015 Arruda-Carvalho and Clem. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Arruda-Carvalho, Maithe Clem, Roger L. Prefrontal-amygdala fear networks come into focus |
title | Prefrontal-amygdala fear networks come into focus |
title_full | Prefrontal-amygdala fear networks come into focus |
title_fullStr | Prefrontal-amygdala fear networks come into focus |
title_full_unstemmed | Prefrontal-amygdala fear networks come into focus |
title_short | Prefrontal-amygdala fear networks come into focus |
title_sort | prefrontal-amygdala fear networks come into focus |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626554/ https://www.ncbi.nlm.nih.gov/pubmed/26578902 http://dx.doi.org/10.3389/fnsys.2015.00145 |
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