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Enteric pathogens deploy cell cycle inhibiting factors to block the bactericidal activity of Perforin-2

Perforin-2 (MPEG1) is an effector of the innate immune system that limits the proliferation and spread of medically relevant Gram-negative, -positive, and acid fast bacteria. We show here that a cullin-RING E3 ubiquitin ligase (CRL) complex containing cullin-1 and βTrCP monoubiquitylates Perforin-2...

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Detalles Bibliográficos
Autores principales:	McCormack, Ryan M, Lyapichev, Kirill, Olsson, Melissa L, Podack, Eckhard R, Munson, George P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2015
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626573/ https://www.ncbi.nlm.nih.gov/pubmed/26418746 http://dx.doi.org/10.7554/eLife.06505

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