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Comparative Ochratoxin Toxicity: A Review of the Available Data

Ochratoxins are a group of mycotoxins produced by a variety of moulds. Ochratoxin A (OTA), the most prominent member of this toxin family, was first described by van der Merwe et al. in Nature in 1965. Dietary exposure to OTA represents a serious health issue and has been associated with several hum...

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Autores principales: Heussner, Alexandra H., Bingle, Lewis E. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626733/
https://www.ncbi.nlm.nih.gov/pubmed/26506387
http://dx.doi.org/10.3390/toxins7104253
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author Heussner, Alexandra H.
Bingle, Lewis E. H.
author_facet Heussner, Alexandra H.
Bingle, Lewis E. H.
author_sort Heussner, Alexandra H.
collection PubMed
description Ochratoxins are a group of mycotoxins produced by a variety of moulds. Ochratoxin A (OTA), the most prominent member of this toxin family, was first described by van der Merwe et al. in Nature in 1965. Dietary exposure to OTA represents a serious health issue and has been associated with several human and animal diseases including poultry ochratoxicosis, porcine nephropathy, human endemic nephropathies and urinary tract tumours in humans. More than 30 years ago, OTA was shown to be carcinogenic in rodents and since then extensive research has been performed in order to investigate its mode of action, however, this is still under debate. OTA is regarded as the most toxic family member, however, other ochratoxins or their metabolites and, in particular, ochratoxin mixtures or combinations with other mycotoxins may represent serious threats to human and animal health. This review summarises and evaluates current knowledge about the differential and comparative toxicity of the ochratoxin group.
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spelling pubmed-46267332015-11-12 Comparative Ochratoxin Toxicity: A Review of the Available Data Heussner, Alexandra H. Bingle, Lewis E. H. Toxins (Basel) Review Ochratoxins are a group of mycotoxins produced by a variety of moulds. Ochratoxin A (OTA), the most prominent member of this toxin family, was first described by van der Merwe et al. in Nature in 1965. Dietary exposure to OTA represents a serious health issue and has been associated with several human and animal diseases including poultry ochratoxicosis, porcine nephropathy, human endemic nephropathies and urinary tract tumours in humans. More than 30 years ago, OTA was shown to be carcinogenic in rodents and since then extensive research has been performed in order to investigate its mode of action, however, this is still under debate. OTA is regarded as the most toxic family member, however, other ochratoxins or their metabolites and, in particular, ochratoxin mixtures or combinations with other mycotoxins may represent serious threats to human and animal health. This review summarises and evaluates current knowledge about the differential and comparative toxicity of the ochratoxin group. MDPI 2015-10-22 /pmc/articles/PMC4626733/ /pubmed/26506387 http://dx.doi.org/10.3390/toxins7104253 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Heussner, Alexandra H.
Bingle, Lewis E. H.
Comparative Ochratoxin Toxicity: A Review of the Available Data
title Comparative Ochratoxin Toxicity: A Review of the Available Data
title_full Comparative Ochratoxin Toxicity: A Review of the Available Data
title_fullStr Comparative Ochratoxin Toxicity: A Review of the Available Data
title_full_unstemmed Comparative Ochratoxin Toxicity: A Review of the Available Data
title_short Comparative Ochratoxin Toxicity: A Review of the Available Data
title_sort comparative ochratoxin toxicity: a review of the available data
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626733/
https://www.ncbi.nlm.nih.gov/pubmed/26506387
http://dx.doi.org/10.3390/toxins7104253
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