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Beneficial effects of low dose radiation in response to the oncogenic KRAS induced cellular transformation
Recently low dose irradiation has gained attention in the field of radiotherapy. For lack of understanding of the molecular consequences of low dose irradiation, there is much doubt concerning its risks on human beings. In this article, we report that low dose irradiation is capable of blocking the...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626770/ https://www.ncbi.nlm.nih.gov/pubmed/26515758 http://dx.doi.org/10.1038/srep15809 |
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author | Kim, Rae-Kwon Kim, Min-Jung Seong, Ki Moon Kaushik, Neha Suh, Yongjoon Yoo, Ki-Chun Cui, Yan-Hong Jin, Young Woo Nam, Seon Young Lee, Su-Jae |
author_facet | Kim, Rae-Kwon Kim, Min-Jung Seong, Ki Moon Kaushik, Neha Suh, Yongjoon Yoo, Ki-Chun Cui, Yan-Hong Jin, Young Woo Nam, Seon Young Lee, Su-Jae |
author_sort | Kim, Rae-Kwon |
collection | PubMed |
description | Recently low dose irradiation has gained attention in the field of radiotherapy. For lack of understanding of the molecular consequences of low dose irradiation, there is much doubt concerning its risks on human beings. In this article, we report that low dose irradiation is capable of blocking the oncogenic KRAS-induced malignant transformation. To address this hypothesis, we showed that low dose irradiation, at doses of 0.1 Gray (Gy); predominantly provide defensive response against oncogenic KRAS -induced malignant transformation in human cells through the induction of antioxidants without causing cell death and acts as a critical regulator for the attenuation of reactive oxygen species (ROS). Importantly, we elucidated that knockdown of antioxidants significantly enhanced ROS generation, invasive and migratory properties and abnormal acini formation in KRAS transformed normal as well as cancer cells. Taken together, this study demonstrates that low dose irradiation reduces the KRAS induced malignant cellular transformation through diminution of ROS. This interesting phenomenon illuminates the beneficial effects of low dose irradiation, suggesting one of contributory mechanisms for reducing the oncogene induced carcinogenesis that intensify the potential use of low dose irradiation as a standard regimen. |
format | Online Article Text |
id | pubmed-4626770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46267702015-11-03 Beneficial effects of low dose radiation in response to the oncogenic KRAS induced cellular transformation Kim, Rae-Kwon Kim, Min-Jung Seong, Ki Moon Kaushik, Neha Suh, Yongjoon Yoo, Ki-Chun Cui, Yan-Hong Jin, Young Woo Nam, Seon Young Lee, Su-Jae Sci Rep Article Recently low dose irradiation has gained attention in the field of radiotherapy. For lack of understanding of the molecular consequences of low dose irradiation, there is much doubt concerning its risks on human beings. In this article, we report that low dose irradiation is capable of blocking the oncogenic KRAS-induced malignant transformation. To address this hypothesis, we showed that low dose irradiation, at doses of 0.1 Gray (Gy); predominantly provide defensive response against oncogenic KRAS -induced malignant transformation in human cells through the induction of antioxidants without causing cell death and acts as a critical regulator for the attenuation of reactive oxygen species (ROS). Importantly, we elucidated that knockdown of antioxidants significantly enhanced ROS generation, invasive and migratory properties and abnormal acini formation in KRAS transformed normal as well as cancer cells. Taken together, this study demonstrates that low dose irradiation reduces the KRAS induced malignant cellular transformation through diminution of ROS. This interesting phenomenon illuminates the beneficial effects of low dose irradiation, suggesting one of contributory mechanisms for reducing the oncogene induced carcinogenesis that intensify the potential use of low dose irradiation as a standard regimen. Nature Publishing Group 2015-10-30 /pmc/articles/PMC4626770/ /pubmed/26515758 http://dx.doi.org/10.1038/srep15809 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Kim, Rae-Kwon Kim, Min-Jung Seong, Ki Moon Kaushik, Neha Suh, Yongjoon Yoo, Ki-Chun Cui, Yan-Hong Jin, Young Woo Nam, Seon Young Lee, Su-Jae Beneficial effects of low dose radiation in response to the oncogenic KRAS induced cellular transformation |
title | Beneficial effects of low dose radiation in response to the oncogenic KRAS induced cellular transformation |
title_full | Beneficial effects of low dose radiation in response to the oncogenic KRAS induced cellular transformation |
title_fullStr | Beneficial effects of low dose radiation in response to the oncogenic KRAS induced cellular transformation |
title_full_unstemmed | Beneficial effects of low dose radiation in response to the oncogenic KRAS induced cellular transformation |
title_short | Beneficial effects of low dose radiation in response to the oncogenic KRAS induced cellular transformation |
title_sort | beneficial effects of low dose radiation in response to the oncogenic kras induced cellular transformation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626770/ https://www.ncbi.nlm.nih.gov/pubmed/26515758 http://dx.doi.org/10.1038/srep15809 |
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