Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum activity. Perforin-2 is expressed constitutively in phagocytes and inducibly in parenchymal, tissue-forming cells. In vitro, Perforin-2 prevents the intracellular replication and proliferation of bacterial pathogens in t...

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Detalles Bibliográficos
Autores principales: McCormack, Ryan M, de Armas, Lesley R, Shiratsuchi, Motoaki, Fiorentino, Desiree G, Olsson, Melissa L, Lichtenheld, Mathias G, Morales, Alejo, Lyapichev, Kirill, Gonzalez, Louis E, Strbo, Natasa, Sukumar, Neelima, Stojadinovic, Olivera, Plano, Gregory V, Munson, George P, Tomic-Canic, Marjana, Kirsner, Robert S, Russell, David G, Podack, Eckhard R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4626811/
https://www.ncbi.nlm.nih.gov/pubmed/26402460
http://dx.doi.org/10.7554/eLife.06508

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