Cargando…

Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers

The associations between Bisphenol-A (BPA) exposure and reproductive hormone levels among women are unclear. A cross-sectional study was conducted among female workers from BPA-exposed and unexposed factories in China. Women’s blood samples were collected for assay of follicle-stimulating hormone (F...

Descripción completa

Detalles Bibliográficos
Autores principales: Miao, Maohua, Yuan, Wei, Yang, Fen, Liang, Hong, Zhou, Zhijun, Li, Runsheng, Gao, Ersheng, Li, De-Kun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627028/
https://www.ncbi.nlm.nih.gov/pubmed/26506366
http://dx.doi.org/10.3390/ijerph121013240
_version_ 1782398206978555904
author Miao, Maohua
Yuan, Wei
Yang, Fen
Liang, Hong
Zhou, Zhijun
Li, Runsheng
Gao, Ersheng
Li, De-Kun
author_facet Miao, Maohua
Yuan, Wei
Yang, Fen
Liang, Hong
Zhou, Zhijun
Li, Runsheng
Gao, Ersheng
Li, De-Kun
author_sort Miao, Maohua
collection PubMed
description The associations between Bisphenol-A (BPA) exposure and reproductive hormone levels among women are unclear. A cross-sectional study was conducted among female workers from BPA-exposed and unexposed factories in China. Women’s blood samples were collected for assay of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17β-Estradiol (E2), prolactin (PRL), and progesterone (PROG). Their urine samples were collected for BPA measurement. In the exposed group, time weighted average exposure to BPA for an 8-h shift (TWA8), a measure incorporating historic exposure level, was generated based on personal air sampling. Multiple linear regression analyses were used to examine linear associations between urine BPA concentration and reproductive hormones after controlling for potential confounders. A total of 106 exposed and 250 unexposed female workers were included in this study. A significant positive association between increased urine BPA concentration and higher PRL and PROG levels were observed. Similar associations were observed after the analysis was carried out separately among the exposed and unexposed workers. In addition, a positive association between urine BPA and E2 was observed among exposed workers with borderline significance, while a statistically significant inverse association between urine BPA and FSH was observed among unexposed group. The results suggest that BPA exposure may lead to alterations in female reproductive hormone levels.
format Online
Article
Text
id pubmed-4627028
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-46270282015-11-12 Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers Miao, Maohua Yuan, Wei Yang, Fen Liang, Hong Zhou, Zhijun Li, Runsheng Gao, Ersheng Li, De-Kun Int J Environ Res Public Health Article The associations between Bisphenol-A (BPA) exposure and reproductive hormone levels among women are unclear. A cross-sectional study was conducted among female workers from BPA-exposed and unexposed factories in China. Women’s blood samples were collected for assay of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17β-Estradiol (E2), prolactin (PRL), and progesterone (PROG). Their urine samples were collected for BPA measurement. In the exposed group, time weighted average exposure to BPA for an 8-h shift (TWA8), a measure incorporating historic exposure level, was generated based on personal air sampling. Multiple linear regression analyses were used to examine linear associations between urine BPA concentration and reproductive hormones after controlling for potential confounders. A total of 106 exposed and 250 unexposed female workers were included in this study. A significant positive association between increased urine BPA concentration and higher PRL and PROG levels were observed. Similar associations were observed after the analysis was carried out separately among the exposed and unexposed workers. In addition, a positive association between urine BPA and E2 was observed among exposed workers with borderline significance, while a statistically significant inverse association between urine BPA and FSH was observed among unexposed group. The results suggest that BPA exposure may lead to alterations in female reproductive hormone levels. MDPI 2015-10-22 2015-10 /pmc/articles/PMC4627028/ /pubmed/26506366 http://dx.doi.org/10.3390/ijerph121013240 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Miao, Maohua
Yuan, Wei
Yang, Fen
Liang, Hong
Zhou, Zhijun
Li, Runsheng
Gao, Ersheng
Li, De-Kun
Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers
title Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers
title_full Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers
title_fullStr Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers
title_full_unstemmed Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers
title_short Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers
title_sort associations between bisphenol a exposure and reproductive hormones among female workers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627028/
https://www.ncbi.nlm.nih.gov/pubmed/26506366
http://dx.doi.org/10.3390/ijerph121013240
work_keys_str_mv AT miaomaohua associationsbetweenbisphenolaexposureandreproductivehormonesamongfemaleworkers
AT yuanwei associationsbetweenbisphenolaexposureandreproductivehormonesamongfemaleworkers
AT yangfen associationsbetweenbisphenolaexposureandreproductivehormonesamongfemaleworkers
AT lianghong associationsbetweenbisphenolaexposureandreproductivehormonesamongfemaleworkers
AT zhouzhijun associationsbetweenbisphenolaexposureandreproductivehormonesamongfemaleworkers
AT lirunsheng associationsbetweenbisphenolaexposureandreproductivehormonesamongfemaleworkers
AT gaoersheng associationsbetweenbisphenolaexposureandreproductivehormonesamongfemaleworkers
AT lidekun associationsbetweenbisphenolaexposureandreproductivehormonesamongfemaleworkers