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Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers
The associations between Bisphenol-A (BPA) exposure and reproductive hormone levels among women are unclear. A cross-sectional study was conducted among female workers from BPA-exposed and unexposed factories in China. Women’s blood samples were collected for assay of follicle-stimulating hormone (F...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627028/ https://www.ncbi.nlm.nih.gov/pubmed/26506366 http://dx.doi.org/10.3390/ijerph121013240 |
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author | Miao, Maohua Yuan, Wei Yang, Fen Liang, Hong Zhou, Zhijun Li, Runsheng Gao, Ersheng Li, De-Kun |
author_facet | Miao, Maohua Yuan, Wei Yang, Fen Liang, Hong Zhou, Zhijun Li, Runsheng Gao, Ersheng Li, De-Kun |
author_sort | Miao, Maohua |
collection | PubMed |
description | The associations between Bisphenol-A (BPA) exposure and reproductive hormone levels among women are unclear. A cross-sectional study was conducted among female workers from BPA-exposed and unexposed factories in China. Women’s blood samples were collected for assay of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17β-Estradiol (E2), prolactin (PRL), and progesterone (PROG). Their urine samples were collected for BPA measurement. In the exposed group, time weighted average exposure to BPA for an 8-h shift (TWA8), a measure incorporating historic exposure level, was generated based on personal air sampling. Multiple linear regression analyses were used to examine linear associations between urine BPA concentration and reproductive hormones after controlling for potential confounders. A total of 106 exposed and 250 unexposed female workers were included in this study. A significant positive association between increased urine BPA concentration and higher PRL and PROG levels were observed. Similar associations were observed after the analysis was carried out separately among the exposed and unexposed workers. In addition, a positive association between urine BPA and E2 was observed among exposed workers with borderline significance, while a statistically significant inverse association between urine BPA and FSH was observed among unexposed group. The results suggest that BPA exposure may lead to alterations in female reproductive hormone levels. |
format | Online Article Text |
id | pubmed-4627028 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-46270282015-11-12 Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers Miao, Maohua Yuan, Wei Yang, Fen Liang, Hong Zhou, Zhijun Li, Runsheng Gao, Ersheng Li, De-Kun Int J Environ Res Public Health Article The associations between Bisphenol-A (BPA) exposure and reproductive hormone levels among women are unclear. A cross-sectional study was conducted among female workers from BPA-exposed and unexposed factories in China. Women’s blood samples were collected for assay of follicle-stimulating hormone (FSH), luteinizing hormone (LH), 17β-Estradiol (E2), prolactin (PRL), and progesterone (PROG). Their urine samples were collected for BPA measurement. In the exposed group, time weighted average exposure to BPA for an 8-h shift (TWA8), a measure incorporating historic exposure level, was generated based on personal air sampling. Multiple linear regression analyses were used to examine linear associations between urine BPA concentration and reproductive hormones after controlling for potential confounders. A total of 106 exposed and 250 unexposed female workers were included in this study. A significant positive association between increased urine BPA concentration and higher PRL and PROG levels were observed. Similar associations were observed after the analysis was carried out separately among the exposed and unexposed workers. In addition, a positive association between urine BPA and E2 was observed among exposed workers with borderline significance, while a statistically significant inverse association between urine BPA and FSH was observed among unexposed group. The results suggest that BPA exposure may lead to alterations in female reproductive hormone levels. MDPI 2015-10-22 2015-10 /pmc/articles/PMC4627028/ /pubmed/26506366 http://dx.doi.org/10.3390/ijerph121013240 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Miao, Maohua Yuan, Wei Yang, Fen Liang, Hong Zhou, Zhijun Li, Runsheng Gao, Ersheng Li, De-Kun Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers |
title | Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers |
title_full | Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers |
title_fullStr | Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers |
title_full_unstemmed | Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers |
title_short | Associations between Bisphenol A Exposure and Reproductive Hormones among Female Workers |
title_sort | associations between bisphenol a exposure and reproductive hormones among female workers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627028/ https://www.ncbi.nlm.nih.gov/pubmed/26506366 http://dx.doi.org/10.3390/ijerph121013240 |
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